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Table 2 Whole genome comparison of real versus randomized miRNAs against the complete genomes of D. melanogaster and D. pseudoobscura

From: MicroRNA targets in Drosophila

  Total hits Total conserved hits 1 site ≥ 2 sites
73 D. melanogaster miRNAs (A) 6,864 589 556 33
73 Random miRNAs (B) 5,152 204 201 3
Standard deviation (100 experiments) ± 132 ± 43 ± 40 ± 3
Ratio (A/B)   2.9 2.8 11.0
Estimated false positives (%)   35% 36% 9%
  1. Detected conserved hits (especially those with multiple detected sites in the 3' UTR) are significantly over-represented (2.8× and 11× as many cases, on average, respectively) in analyses with actual miRNAs compared to randomly shuffled miRNAs. The thresholds used for this analysis were S: 100; ΔG: -19 kcal/mol; ID: 70%.