Figure 7
Comparison of the genomic organization of the leucine biosynthesis genes in M. tuberculosis and Schizosaccharomyces pombe. (a) Genomic organization of the leuC and leuD genes of M. tuberculosis. (b) S. pombe alpha-isopropylmalate isomerase, containing both the leuC and leuD coding regions in a single fusion gene. This example illustrates the power of the Rosetta Stone, Phylogenetic Profile, Gene Neighbor and Operon methods to infer a functional linkage, in this case one that is already established [18].