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Table 3 Third position (f2) values for the Kv3 K+ channels

From: Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster

Spec 1 Spec 2 f2 c2 n2
Mouse3.1 Aptero3.3 0.71 74 105
  Hum3.1 0.85 116 136
  LobstKv3 0.51 34 67
  Dros3.1 0.58 40 69
  Agam3.1 0.69 47 68
  Agam3.2 0.75 47 63
  Dros3.2 0.58 32 55
  Agam3.3 0.66 41 62
Hum3.1 LobstKv3 0.54 65 121
  Dros3.1 0.60 71 119
  Agam3.1 0.52 60 115
  Agam3.2 0.56 49 88
  Dros3.2 0.54 53 99
  Agam3.3 0.68 42 62
LobstKv3 Dros3.1 0.54 65 121
  Agam3.1 0.60 71 119
  Agam3.2 0.52 60 115
  Dros3.2 0.56 49 88
  Agam3.3 0.54 53 99
Dros3.1 Agam3.1 0.61 79 129
  Agam3.2 0.65 81 124
  Dros3.2 0.61 53 89
  Agam3.3 0.62 62 100
Agam3.1 Agam3.2 0.74 93 126
  Dros3.2 0.55 47 85
  Agam3.3 0.75 72 96
Agam3.2 Dros3.2 0.57 47 83
  Agam3.3 0.69 63 92
Dros3.2 Agam3.3 0.52 52 101
Dros Kv1 AgamKv1 0.69 69 100
Dros Kv2 Agam Kv2 0.73 73 101
Dros Kv4 Agam Kv4 0.69 80 114
  1. Calculations are based on alignments spanning the first through the sixth transmembrane domain. The n2 value indicates number of twofold degenerate amino acids, c2 indicates the number of twofold degenerate amino acids with conserved third-position nucleotides, and f2 signifies the percentage of conserved third-position nucleotides at these positions (that is, c2/n2). Interspecies orthologs between fly and mosquito (and between mouse and human, near top) are shown in bold, and intraspecies paralogs are shown in underline and italics. Comparisons of lower f2 values (for example, 0.55 vs 0.50) are not as meaningful (with respect to estimating divergence dates) as higher-value comparisons owing to equilibration within the lower ranges. Agam, A. gambiae; Dros, D. melanogaster; Lobst, Panulirus interruptus; Hum, Homo sapiens.