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Table 2 List of ORFs in E. coli with updated annotations based on sequence similarity

From: An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)

EC number Bnum Gene Published annotation [12] Suggested annotation
1.1.1.48 b1315 ycjS Putative NADH-dependent dehydrogenase D-Galactose 1-dehydrogenase
1.1.1.48 b1624 ydgJ Putative NAD(P)-binding dehydrogenase D-Galactose 1-dehydrogenase
1.1.1.48 b3440 yhhX Putative NAD(P)-binding dehydrogenase D-Galactose 1-dehydrogenase
1.1.1.5 b2426 ucpA Putative oxidoreductase, NAD(P)-binding Acetoin dehydrogenase, diacetyl reductase
1.1.1.5 b2137 yohF Putative oxidoreductase Acetoin dehydrogenase, diacetyl reductase
1.1.1.5 b4266 idnO 5-Keto-D-gluconate-5-reductase Acetoin dehydrogenase, diacetyl reductase
1.2.1.19 b1385 feaB Phenylacetaldehyde dehydrogenase Aminobutyraldehyde dehydrogenase
1.2.1.19 b1444 ydcW Putative aldehyde dehydrogenase Aminobutyraldehyde dehydrogenase
1.2.1.19 b3588 aldB Aldehyde dehydrogenase B (lactaldehyde dehydrogenase) Aminobutyraldehyde dehydrogenase
1.2.1.24 b1385 feaB Phenylacetaldehyde dehydrogenase Succinate-semialdehyde dehydrogenase
1.2.1.24 b1444 ydcW Putative aldehyde dehydrogenase Succinate-semialdehyde dehydrogenase
1.2.1.24 b1415 aldA Aldehyde dehydrogenase A, NAD-linked Succinate-semialdehyde dehydrogenase
1.2.7.1 b1378 nifJ Putative pyruvate-flavodoxin oxidoreductase Pyruvate synthase
1.3.1.2 b2146 yeiT Putative glutamate synthase Dihydrothymine dehydrogenase
1.3.1.2 b2147 yeiA Putative dihydropyrimidine dehydrogenase, FMN-linked Dihydrothymine dehydrogenase
1.3.1.2 b2878 b2878 Putative oxidoreductase Dihydrothymine dehydrogenase
1.3.99.3 b1695 ydiO Putative acyl-CoA dehydrogenase Acyl-CoA dehydrogenase
1.3.99.3 b0039 caiA Putative acyl-CoA dehydrogenase, carnitine metabolism Acyl-CoA dehydrogenase
1.3.99.3 b4187 aidB Putative acyl-CoA dehydrogenase; adaptive response (transcription activated by Ada) Acyl-CoA dehydrogenase
1.6.6.9 b3551 bisC Biotin sulfoxide reductase Trimethylamine-N-oxide reductase (TMAO reductase II)
1.6.6.9 b1587 b1587 Putative reductase Trimethylamine-N-oxide reductase (TMAO reductase II)
1.6.6.9 b1588 b1588 Putative reductase Trimethylamine-N-oxide reductase (TMAO reductase II)
1.6.99.2 b0046 yabF Putative electron transfer flavoprotein-NAD/FAD/quinone oxidoreductase, subunit for KefC K+ efflux system NAD(P)H dehydrogenase
1.6.99.2 b3351 yheR Putative electron transfer flavoprotein-NAD/FAD/quinone oxidoreductase NAD(P)H dehydrogenase
1.6.99.2 b0901 ycaK Putative electron transfer flavoprotein-NAD/FAD/quinone oxidoreductase NAD(P)H dehydrogenase
2.3.3.11 (formerly 4.1.3.9) b2264 menD Bifunctional modular MenD: 2-oxoglutarate decarboxylase and SHCHC synthase 2-Hydroxyglutarate synthase
2.3.3.11 (formerly 4.1.3.9) b3671 ilvB Acetolactate synthase I, large subunit, valine-sensitive, FAD and thiamine PPi binding 2-Hydroxyglutarate synthase
2.7.1.23 b2615 yfjB Conserved protein NAD+ kinase
2.7.1.23 b3916 pfkA 6-phosphofructokinase I NAD+ kinase
2.7.2.1 b3115 tdcD Propionate kinase/acetate kinase II, anaerobic Acetate kinase (ackB)
2.7.8.2 b1408 b1408 Putative enzyme Diacylglycerol cholinephosphotransferase
2.8.1.2 b2521 sseA Putative sulfurtransferase 3-Mercaptopyruvate sulfurtransferase
2.8.1.2 b1757 ynjE Putative thiosulfate sulfur transferase 3-Mercaptopyruvate sulfurtransferase
2.8.3.8 b2222 atoA Acetyl-CoA:acetoacetyl-CoA transferase, beta subunit Acetate CoA-transferase
2.8.3.8 b2221 atoD Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit Acetate CoA-transferase
2.8.3.8 b1694 ydiF Putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit Acetate CoA-transferase
3.1.1.31 b0678 nagB Glucosamine-6-phosphate deaminase 6-Phosphogluconolactonase (Pgl)
3.1.1.31 b3718 yieK Putative isomerase 6-Phosphogluconolactonase (Pgl)
3.1.1.31 b3141 agaI Putative galactosamine-6-phosphate isomerase 6-Phosphogluconolactonase (Pgl)
3.2.1.68 b3431 glgX Glycosyl hydrolase Isoamylase
3.5.1.2 b1524 yneH Putative glutaminase Glutaminase A or B
3.5.1.2 b0485 ybaS Putative glutaminase Glutaminase A or B
3.6.1.19 b2954 yggV Conserved hypothetical protein Nucleoside-triphosphate (ITP) diphosphatase
3.6.1.22 b3996 yjaD Conserved hypothetical protein, MutT-like protein NAD+ diphosphatase
3.6.1.5 b3615 yibD Putative glycosyltransferase Inosine triphosphate diphosphatase
3.6.1.6 b3614 yibQ Conserved hypothetical protein Nucleoside (IDP) diphosphatase
4.1.1.39 b3615 yibD Putative glycosyltransferase Ribulose-bisphosphate carboxylase (2-phosphoglycolate forming)
4.1.2.10 b0311 betA Choline dehydrogenase, a flavoprotein Hydroxynitrile lyase
4.1.2.10 b3168 infB Protein chain initiation factor IF-2 Hydroxynitrile lyase
4.2.1.66 b3022 ygiU Conserved protein Cyanide hydratase
6.2.1.12 b4069 acs Acetyl-CoA synthetase Hydroxycinnamate-CoA ligase
6.2.1.12 b1701 ydiD Putative CoA-dependent ligase Hydroxycinnamate-CoA ligase
6.2.1.12 b2836 aas bifunctional multimodular Aas: 2-acylglycerophospho-ethanolamine acyl transferase Hydroxycinnamate-CoA ligase
6.2.1.4 b0728 sucC Succinyl-CoA synthetase, beta subunit Succinate-CoA ligase (ITP forming)
6.2.1.4 b0729 sucD Succinyl-CoA synthetase, alpha subunit, NAD(P) binding Succinate-CoA ligase (ITP forming)
  1. Annotations shown in bold arose from analyzing the network gaps in iJR904.