Figure 1
From: CpG content affects gene silencing in mice: evidence from novel transgenes
EF1αLacZ reporter genes with different CpG content. All four constructs share the same promoter region (EF1) from the human EF1α (translation elongation factor 1, α subunit) gene including the exon 1 (e1) and a part of exon 2 (e2), a polyadenylation sign (poly(A)) from Moloney murine virus and a nuclear locating signal (nls) from the large T antigen of SV40 [32]. Both the left and right arms of the YAC (green line) are 60-70 kb long. Each vertical bar corresponds to a CpG dinucleotide. The percentage of CpGs in the reporter gene is indicated on the right.