Recent segmental and gene duplications in the mouse genome

Table 5 Genes that have undergone recent duplication in both the mouse and human genome*

Refseq^†	Gene description
NM_007534	B-cell leukemia/lymphoma 2 related protein A1b (Bcl2a1b)
NM_007558	Bone morphogenetic protein 8a (Bmp8a)
NM_007812	Cytochrome P450, 2a5 (Cyp2a5)
NM_008181	Glutathione S-transferase, alpha 1 (Ya) (Gsta1)
NM_010390	Histocompatibility 2, Q region locus 1 (H2Q1)
NM_009467	UDP-glucuronosyltransferase 2 family, member 5 (Ugt2b5)
NM_009669	Amylase 2, pancreatic (Amy2)
NM_009888	Complement component factor h (Cfh)
NM_010856	Myosin heavy chain, cardiac muscle, adult (Myhca)
NM_013778	Aldo-keto reductase family 1, member C13 (Akr1c13)
NM_022033	3-Oxoacid CoA transferase 2 (Oxct2) (Imbedded in the Bmp8a gene)
NM_026419	Elastase 3B, pancreatic (Ela3b)
NM_031176	Tenascin XB (Tnxb)
NM_130864	Acetyl-coenzyme A acyltransferase (peroxisomal 3-oxoacyl-Coenzyme athiolase) (Acaa)
NM_010997	Olfactory receptor 54 (Olfr54)
NM_031170	Keratin complex 2, basic, gene 8 (Krt2-8)

*Six hundred and seventy-five duplicated mouse gene sequences were aligned to the June 2002 human genome assembly by BLAST (with an initial expected value cutoff of <10^-10). The best aligned human genes were subsequently used for reciprocal BLAST alignments (against the mouse genome sequence) to establish a putative orthologous relationship between the mouse and human gene pairs. Using results from our human genome duplication analysis [9, 37], we examined regions of the human genome where the human genes are involved in recent segmental duplication. ^†Italics represents genes that are entirely within a duplication in the mouse genome.

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