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Table 2 Significantly enriched classes arising both in genes higher in A549 cell cultures over tumors and in genes higher in U118 cell cultures over tumors (p < 0.05 in both sets)

From: Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice

Category Term Gene count in A549 set of 223 Gene count in U118 set of 256 Gene count in entire set of 5,682 p-value A549 set p-value U118 set
GO term annotation (0.95 terms expected, found 46)
Biological process Alcohol metabolism 10 15 110 1.07E-02 1.06E-04
Biological process Aromatic compound metabolism 7 6 23 1.87E-05 4.16E-04
Biological process Biosynthesis 31 27 330 3.88E-06 1.69E-03
Biological process Cell cycle 31 33 327 3.20E-06 8.11E-06
Biological process Cell proliferation 36 39 535 7.98E-04 1.53E-03
Biological process Cytokinesis 8 6 39 1.06E-04 7.36E-03
Biological process DNA metabolism 16 12 120 1.52E-05 7.46E-03
Biological process DNA replication 13 10 81 1.30E-05 3.22E-03
Biological process G1/S transition of mitotic cell cycle 5 7 39 1.73E-02 1.55E-03
Biological process Metabolism 108 134 2278 6.12E-03 3.34E-05
Biological process Mitotic cell cycle 9 10 54 2.14E-04 1.20E-04
Biological process Nucleotide biosynthesis 10 5 31 1.52E-07 1.16E-02
Biological process Regulation of CDK activity 5 6 23 1.68E-03 4.16E-04
Biological process Tricarboxylic acid cycle 3 5 12 1.01E-02 1.09E-04
Molecular function ATP binding activity 29 33 425 2.18E-03 1.28E-03
Molecular function Cyclin-dependent protein kinase activity 6 8 25 3.23E-04 8.44E-06
Molecular function Enzyme activity 90 109 1466 8.76E-07 1.70E-09
Molecular function Ligase activity 14 11 72 5.40E-07 3.28E-04
Molecular function Lyase activity 8 8 75 8.69E-03 1.88E-02
Molecular function Nucleotide binding activity 40 42 564 1.28E-04 6.40E-04
MeSH term association (2.2 terms expected, found 37)
Anatomy Intracellular membranes 21 30 344 2.79E-02 3.20E-04
Anatomy Mitochondria 38 52 607 2.17E-03 2.46E-06
Biological sciences Active transport, Cell nucleus 23 23 329 4.68E-03 2.26E-02
Biological sciences Cell cycle 62 66 980 4.19E-05 2.82E-04
Biological sciences DNA replication 30 33 440 1.84E-03 2.28E-03
Biological sciences Genes, lethal 17 16 211 3.61E-03 2.78E-02
Biological sciences Mitosis 28 37 484 2.30E-02 8.57E-04
Biological sciences Mutagenesis 52 55 940 4.84E-03 2.07E-02
Biological sciences Oxidative stress 30 36 454 2.98E-03 5.13E-04
Biological sciences S phase 21 22 272 2.12E-03 5.18E-03
Chemicals and drugs Acetyl coenzyme A 4 4 24 1.32E-02 2.10E-02
Chemicals and drugs Adenosinetriphosphatase 30 36 416 7.50E-04 9.02E-05
Chemicals and drugs Antineoplastic agents 49 55 897 8.09E-03 8.39E-03
Chemicals and drugs Cyclin B 10 15 101 5.96E-03 3.87E-05
Chemicals and drugs Cyclin-dependent kinases 21 30 336 2.22E-02 2.12E-04
Chemicals and drugs Cysteine endopeptidases 26 29 418 1.21E-02 1.22E-02
Chemicals and drugs Multienzyme complexes 35 35 512 7.14E-04 7.58E-03
Chemicals and drugs Phosphoglucomutase 5 6 30 5.68E-03 1.88E-03
Chemicals and drugs RNA nucleotidyltransferases 5 5 33 8.60E-03 1.51E-02
Diseases Carcinoma in situ 6 7 55 1.99E-02 1.11E-02