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Table 1 Top 30 genes showing higher expression in xenograft tumors over cultures for each cell line ranked by fold change

From: Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice

Probe set Gene Gene product description
Higher in U118 tumors over cultures (p < 0.01, fold change > 5)
V00594_s_at MT2A Metallothionein 2a
M33552_at LSP1 Lymphocyte-specific protein 1
U41518_at AQP1 Aquaporin 1 (channel-forming integral protein, 28 kD)
Z24680_at GARP Glycoprotein A repetitions predominant
J04599_at BGN Biglycan
J03278_at PDGFRB Platelet-derived growth factor receptor, beta polypeptide
M11718_at COL5A2 Collagen, type V, alpha 2
L08096_s_at TNFSF7 Tumor necrosis factor (ligand) superfamily, member 7
D87002_cds2_at POM121L1 Similar to rat integral membrane glycoprotein POM121
HG2994-HT4850_s_at ELN Elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)
Z74615_at COL1A1 Collagen, type I, alpha 1
M57399_at PTN Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
L07807_s_at DNM1 Dynamin 1
Z74616_s_at COL1A2 Collagen, type I, alpha 2
L38486_at MFAP4 Microfibrillar-associated protein 4
X14885_rna1_s_at TGFB3 Transforming growth factor, beta 3
U24488_s_at TNXB Tenascin XB
D86479_at AEBP1 AE-binding protein 1
M80563_at S100A4 S100 calcium-binding protein A4
M18533_at DMD Dystrophin (muscular dystrophy, Duchenne and Becker types
HG945-HT945_s_at ZNF9 Zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)
M93221_at MRC1 Mannose receptor, C type 1
D12485_at ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase 1
HG1078-HT1078_at FLJ10254 Hypothetical protein FLJ10254
HG2810-HT2921_at HOXA10 Homeo box A10
M24351_cds3_s_at PTHLH Parathyroid hormone-like hormone
D13666_s_at OSF-2 Osteoblast specific factor 2 (fasciclin I-like)
Z37976_at LTBP2 Latent transforming growth factor beta binding protein 2
M35878_at IGFBP3 Insulin-like growth factor binding protein 3
X04412_at GSN Gelsolin (amyloidosis, Finnish type)
Higher in A549 tumors over cultures (p < 0.01, fold change > 10)
Z19574_rna1_at KRT17 Keratin 17
M29540_at CEACAM5 Carcinoembryonic antigen-related cell adhesion molecule 5
M35252_at TM4SF3 Transmembrane 4 superfamily member 3
HG371-HT26388_s_at MUC1 Mucin 1, transmembrane
X52003_at TFF1 Trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)
U40434_at MSLN Mesothelin
Z48314_s_at MUC5AC Mucin 5, subtypes A and C, tracheobronchial/gastric
M57730_at EFNA1 Ephrin-A1
L24203_at TRIM29 Tripartite motif-containing 29
U17760_rna1_at LAMB3 Laminin, beta 3 (nicein (125 kD), kalinin (140 kD), BM600 (125 kD))
U04313_at SERPINB5 Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
J05068_at TCN1 Transcobalamin I (vitamin B12 binding protein, R binder family)
AB006781_s_at LGALS4 Lectin, galactoside-binding, soluble, 4 (galectin 4)
K01396_at SERPINA1 Serine (or cysteine) proteinase inhibitor, clade A), member 1
M27436_s_at F3 Coagulation factor III (thromboplastin, tissue factor)
V01512_rna1_at FOS v-Fos FBJ murine osteosarcoma viral oncogene homolog
M18728_at CEACAM6 Carcinoembryonic antigen-related cell adhesion molecule 6
HG2981-HT3127_s_at CD44 CD44 antigen (homing function and Indian blood group system)
U37283_at MAGP2 Microfibril-associated glycoprotein-2
U78551_at MUC5B Mucin 5, subtype B, tracheobronchial
S77410_at AGTR1 Angiotensin receptor 1
J04469_at CKMT1 Creatine kinase, mitochondrial 1 (ubiquitous)
S73591_at TXNIP Thioredoxin interacting protein
Y00318_at IF I factor (complement)
M35878_at IGFBP3 Insulin-like growth factor binding protein 3
M34309_at ERBB3 v-Erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
M95787_at TAGLN Transgelin
L34155_at LAMA3 Laminin, alpha 3 (nicein (150 kD), kalinin (165 kD), BM600 (150 kD), epilegrin)
U65932_at ECM1 Extracellular matrix protein 1
D87953_at NDRG1 N-Myc downstream regulated
  1. Genes in bold were found upregulated in xenograft tumors over cultures for both cell lines with p < 0.05 in each. For A549, underlined genes were also found upregulated in lung tumors over A549 cultures with p < 0.05. For U118, underlined genes were also found upregulated in brain tumors over U118 cultures with p < 0.05.