EASE identifies themes similar to manually determined themes in a fraction of the time. The four gene lists analyzed by Kayo et al. along with the total time needed for initial analysis are shown for the manual and EASE analyses. For each list, the major biological themes as determined by the authors are shown, as well as all significant (p < 0.05) gene categories as determined by EASE score corrected for multiplicity with the bootstrap function using 10,000 random trials. The time shown for EASE represents initial analysis before running the bootstrap analysis. Themes in common between the authors' themes and the EASE results are highlighted in red.