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Table 2 The 428 human ePKs with known or likely kinase catalytic function

From: Genomic analysis of the eukaryotic protein kinase superfamily: a perspective

Group

Number within group

Family

Number within family

Family members (SUGEN nomenclature)

TK

84

Ack

2

ACK, TNK1

  

Abl

2

ABL, ARG

  

Csk

2

CSK, CTK

  

FAK

2

FAK, PYK2

  

Fer

2

FER, FES

  

JAK

4

JAK1, JAK2, JAK3, TYK2

  

Src

11

BLK, BRK, FGR, FRK, FYN, HCK, LCK, LYN, SRC, SRM, YES

  

Syk

2

SYK, ZAP70

  

Tec

5

BMX, BTK, ITK, TEC, TXK

  

Alk

2

ALK, LTK

  

Axl

3

AXL, MER, TYRO3

  

DDR

2

DDR1, DDR2

  

EGFR

3

EGFR, HER2/ErbB2, HER4/ErbB4

  

Eph

12

EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphB1, EphB2, EphB3, EphB4

  

FGFR

4

FGFR1, FGFR2, FGFR3, FGFR4

  

InsR

3

IGF1R, INSR, IRR

  

Lmr

3

LMR1, LMR2, LMR3

  

Met

2

MET, RON

  

Musk

1

MUSK

  

PDGFR/VEGFR

8

FLT3, FMS, KIT, PDGFRa, PDGFRb, FLT1, FLT4, KDR

  

Ret

1

RET

  

Ror

2

ROR1, ROR2

  

Sev

1

ROS

  

Tie

2

TIE1, TIE2

  

Trk

3

TRKA, TRKB, TRKC

AGC

61

PKA

5

PKACa, PKACb, PKACg, PRKX, PRKY

  

PKG

2

PKG1, PKG2

  

PKC

9

PKCa, PKCb, PKCd, PKCe, PKCg, PKCh, PKCi, PKCt, PKCz

  

AKT

3

AKT1, AKT2, AKT3

  

DMPK

7

CRIK, DMPK1, DMPK2, MRCKa, MRCKb, ROCK1, ROCK2

  

GRK

7

BARK1, BARK2, GPRK4, GPRK5, GPRK6, GPRK7, RHOK

  

MAST

5

MAST1, MAST2, MAST3, MAST4, MASTL

  

NDR

4

LATS1, LATS2, NDR1, NDR2

  

PKB

1

PDK1

  

PKN

3

PKN1, PKN2, PKN3

  

RSK

9

MSK1, MSK2, RSK1, RSK2, RSK3, RSK4, SgK494, p70S6K, p70S6Kb

  

SGK

3

SGK, SGK2, SGK3

  

YANK

3

YANK1, YANK2, YANK3

CAMK

66

CAMK1

5

CaMK1a, CaMK1b, CaMK1d, CaMK1g, CaMK4

  

CAMK2

4

CaMK2a, CaMK2b, CaMK2d, CaMK2g

  

CAMKL

20

AMPKa1, AMPKa2, BRSK1, BRSK2, CHK1, HUNK, LKB1, MARK1, MARK2, MARK3, MARK4, MEL, NIM1, NuaK1, NuaK2, PASK, QIK, QSK, SIK, SNRK

  

DAPK

5

DAPK1, DAPK2, DAPK3, DRAK1, DRAK2

  

DCAMKL

3

DCAMKL1, DCAMKL2, DCAMKL3

  

MAPKAPK

5

MAPKAPK2, MAPKAPK3, MAPKAPK5, MNK1, MNK2

  

MLCK

4

caMLCK, skMLCK, smMLCK, SgK085

  

PHK

2

PHKg1, PHKg2

  

PIM

3

PIM1, PIM2, PIM3

  

PKD

3

PKD1, PKD2, PKD3

  

PSK

1

PSKH1

  

RAD53

1

CHK2

  

Trio

4

Obscn, SPEG, Trad, Trio

  

TSSK

5

SSTK, TSSK1, TSSK2, TSSK3, TSSK

  

CAMK-Unique

1

STK33

CMGC

61

CDK

20

CCRK, CDC2, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CHED, CRK7, PCTAIRE1, PCTAIRE2, PCTAIRE3, PFTAIRE1, PFTAIRE2, PITSLRE

  

MAPK

14

Erk1, Erk2, Erk3, Erk4, Erk5, Erk7, JNK1, JNK2, JNK3, NLK, p38a, p38b, p38d, p38g

  

GSK

2

GSK3A, GSK3B

  

CLK

4

CLK1, CLK2, CLK3, CLK4

  

CDKL

5

CDKL1, CDKL2, CDKL3, CDKL4, CDKL5

  

DYRK

10

DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, HIPK1, HIPK2, HIPK3, HIPK4, PRP4

  

RCK

3

ICK, MAK, MOK

  

SRPK

3

MSSK1, SRPK1, SRPK2

STE

45

STE7

7

MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

  

STE20

28

GCK, HPK1, KHS1, KHS2, LOK, MST1, MST2, MST3, MST4, MYO3A, MYO3B, OSR1, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, SLK, STLK3, TAO1, TAO2, TAO3, YSK1, ZC1/HGK, ZC2/TNIK, ZC3/MINK, ZC4/NRK

  

STE11

8

MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8

  

STE-Unique

2

COT, NIK

TKL

37

IRAK

2

IRAK1, IRAK4

  

LISK

4

LIMK1, LIMK2, TESK1, TESK2

  

LRRK

2

LRRK1, LRRK2

  

MLK

9

DLK, HH498, LZK, MLK1, MLK2, MLK3, MLK4, TAK1, ZAK

  

RAF

3

ARAF, BRAF, RAF1

  

RIPK

5

ANKRD3, RIPK1, RIPK2, RIPK3, SgK288

  

STKR

12

ACTR2, ACTR2B, ALK1, ALK2, ALK4, ALK7, BMPR1A, BMPR1B, BMPR2, MISR2, TGFbR1, TGFbR2

CK1

11

CK1

7

CK1a, CK1a2, CK1d, CK1e, CK1g1, CK1g2, CK1g3

  

TTBK

2

TTBK1, TTBK2

  

VRK

2

VRK1, VRK2

Other

63

Aur

3

AurA, AurB, AurC

  

BUB

1

BUB1

  

Bud32

1

PRPK

  

CAMKK

2

CaMKK1, CaMKK2

  

CDC7

1

CDC7

  

CK2

2

CK2a1, CK2a2

  

IKK

4

IKKa, IKKb, IKKe, TBK1

  

IRE

2

IRE1, IRE2

  

MOS

1

MOS

  

NAK

4

AAK1, BIKE, GAK, MPSK1

  

NEK

11

NEK1, NEK2, NEK3, NEK4, NEK5, NEK6, NEK7, NEK8, NEK9, NEK10, NEK11

  

NKF1

3

SBK, SgK069, SgK110

  

NKF2

1

PINK1

  

NKF4

2

CLIK1, CLIK1L

  

PEK

4

GCN2, HRI, PEK, PKR

  

PLK

4

PLK1, PLK2, PLK3, PLK4

  

TLK

2

TLK1, TLK2

  

TOPK

1

PBK

  

TTK

1

TTK

  

ULK

4

Fused, ULK1, ULK2, ULK3

  

VPS15

1

PIK3R4

  

WEE

3

MYT1, Wee1, Wee1B

  

Wnk

4

Wnk1, Wnk2, Wnk3, Wnk4

  

Other-Unique

2

KIS, SgK496