Table 2 The 428 human ePKs with known or likely kinase catalytic function
From: Genomic analysis of the eukaryotic protein kinase superfamily: a perspective
| Group | Number within group | Family | Number within family | Family members (SUGEN nomenclature) |
|---|---|---|---|---|
| TK | 84 | Ack | 2 | ACK, TNK1 |
| Abl | 2 | ABL, ARG | ||
| Csk | 2 | CSK, CTK | ||
| FAK | 2 | FAK, PYK2 | ||
| Fer | 2 | FER, FES | ||
| JAK | 4 | JAK1, JAK2, JAK3, TYK2 | ||
| Src | 11 | BLK, BRK, FGR, FRK, FYN, HCK, LCK, LYN, SRC, SRM, YES | ||
| Syk | 2 | SYK, ZAP70 | ||
| Tec | 5 | BMX, BTK, ITK, TEC, TXK | ||
| Alk | 2 | ALK, LTK | ||
| Axl | 3 | AXL, MER, TYRO3 | ||
| DDR | 2 | DDR1, DDR2 | ||
| EGFR | 3 | EGFR, HER2/ErbB2, HER4/ErbB4 | ||
| Eph | 12 | EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphB1, EphB2, EphB3, EphB4 | ||
| FGFR | 4 | FGFR1, FGFR2, FGFR3, FGFR4 | ||
| InsR | 3 | IGF1R, INSR, IRR | ||
| Lmr | 3 | LMR1, LMR2, LMR3 | ||
| Met | 2 | MET, RON | ||
| Musk | 1 | MUSK | ||
| PDGFR/VEGFR | 8 | FLT3, FMS, KIT, PDGFRa, PDGFRb, FLT1, FLT4, KDR | ||
| Ret | 1 | RET | ||
| Ror | 2 | ROR1, ROR2 | ||
| Sev | 1 | ROS | ||
| Tie | 2 | TIE1, TIE2 | ||
| Trk | 3 | TRKA, TRKB, TRKC | ||
| AGC | 61 | PKA | 5 | PKACa, PKACb, PKACg, PRKX, PRKY |
| PKG | 2 | PKG1, PKG2 | ||
| PKC | 9 | PKCa, PKCb, PKCd, PKCe, PKCg, PKCh, PKCi, PKCt, PKCz | ||
| AKT | 3 | AKT1, AKT2, AKT3 | ||
| DMPK | 7 | CRIK, DMPK1, DMPK2, MRCKa, MRCKb, ROCK1, ROCK2 | ||
| GRK | 7 | BARK1, BARK2, GPRK4, GPRK5, GPRK6, GPRK7, RHOK | ||
| MAST | 5 | MAST1, MAST2, MAST3, MAST4, MASTL | ||
| NDR | 4 | LATS1, LATS2, NDR1, NDR2 | ||
| PKB | 1 | PDK1 | ||
| PKN | 3 | PKN1, PKN2, PKN3 | ||
| RSK | 9 | MSK1, MSK2, RSK1, RSK2, RSK3, RSK4, SgK494, p70S6K, p70S6Kb | ||
| SGK | 3 | SGK, SGK2, SGK3 | ||
| YANK | 3 | YANK1, YANK2, YANK3 | ||
| CAMK | 66 | CAMK1 | 5 | CaMK1a, CaMK1b, CaMK1d, CaMK1g, CaMK4 |
| CAMK2 | 4 | CaMK2a, CaMK2b, CaMK2d, CaMK2g | ||
| CAMKL | 20 | AMPKa1, AMPKa2, BRSK1, BRSK2, CHK1, HUNK, LKB1, MARK1, MARK2, MARK3, MARK4, MEL, NIM1, NuaK1, NuaK2, PASK, QIK, QSK, SIK, SNRK | ||
| DAPK | 5 | DAPK1, DAPK2, DAPK3, DRAK1, DRAK2 | ||
| DCAMKL | 3 | DCAMKL1, DCAMKL2, DCAMKL3 | ||
| MAPKAPK | 5 | MAPKAPK2, MAPKAPK3, MAPKAPK5, MNK1, MNK2 | ||
| MLCK | 4 | caMLCK, skMLCK, smMLCK, SgK085 | ||
| PHK | 2 | PHKg1, PHKg2 | ||
| PIM | 3 | PIM1, PIM2, PIM3 | ||
| PKD | 3 | PKD1, PKD2, PKD3 | ||
| PSK | 1 | PSKH1 | ||
| RAD53 | 1 | CHK2 | ||
| Trio | 4 | Obscn, SPEG, Trad, Trio | ||
| TSSK | 5 | SSTK, TSSK1, TSSK2, TSSK3, TSSK | ||
| CAMK-Unique | 1 | STK33 | ||
| CMGC | 61 | CDK | 20 | CCRK, CDC2, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CHED, CRK7, PCTAIRE1, PCTAIRE2, PCTAIRE3, PFTAIRE1, PFTAIRE2, PITSLRE |
| MAPK | 14 | Erk1, Erk2, Erk3, Erk4, Erk5, Erk7, JNK1, JNK2, JNK3, NLK, p38a, p38b, p38d, p38g | ||
| GSK | 2 | GSK3A, GSK3B | ||
| CLK | 4 | CLK1, CLK2, CLK3, CLK4 | ||
| CDKL | 5 | CDKL1, CDKL2, CDKL3, CDKL4, CDKL5 | ||
| DYRK | 10 | DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, HIPK1, HIPK2, HIPK3, HIPK4, PRP4 | ||
| RCK | 3 | ICK, MAK, MOK | ||
| SRPK | 3 | MSSK1, SRPK1, SRPK2 | ||
| STE | 45 | STE7 | 7 | MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7 |
| STE20 | 28 | GCK, HPK1, KHS1, KHS2, LOK, MST1, MST2, MST3, MST4, MYO3A, MYO3B, OSR1, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, SLK, STLK3, TAO1, TAO2, TAO3, YSK1, ZC1/HGK, ZC2/TNIK, ZC3/MINK, ZC4/NRK | ||
| STE11 | 8 | MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8 | ||
| STE-Unique | 2 | COT, NIK | ||
| TKL | 37 | IRAK | 2 | IRAK1, IRAK4 |
| LISK | 4 | LIMK1, LIMK2, TESK1, TESK2 | ||
| LRRK | 2 | LRRK1, LRRK2 | ||
| MLK | 9 | DLK, HH498, LZK, MLK1, MLK2, MLK3, MLK4, TAK1, ZAK | ||
| RAF | 3 | ARAF, BRAF, RAF1 | ||
| RIPK | 5 | ANKRD3, RIPK1, RIPK2, RIPK3, SgK288 | ||
| STKR | 12 | ACTR2, ACTR2B, ALK1, ALK2, ALK4, ALK7, BMPR1A, BMPR1B, BMPR2, MISR2, TGFbR1, TGFbR2 | ||
| CK1 | 11 | CK1 | 7 | CK1a, CK1a2, CK1d, CK1e, CK1g1, CK1g2, CK1g3 |
| TTBK | 2 | TTBK1, TTBK2 | ||
| VRK | 2 | VRK1, VRK2 | ||
| Other | 63 | Aur | 3 | AurA, AurB, AurC |
| BUB | 1 | BUB1 | ||
| Bud32 | 1 | PRPK | ||
| CAMKK | 2 | CaMKK1, CaMKK2 | ||
| CDC7 | 1 | CDC7 | ||
| CK2 | 2 | CK2a1, CK2a2 | ||
| IKK | 4 | IKKa, IKKb, IKKe, TBK1 | ||
| IRE | 2 | IRE1, IRE2 | ||
| MOS | 1 | MOS | ||
| NAK | 4 | AAK1, BIKE, GAK, MPSK1 | ||
| NEK | 11 | NEK1, NEK2, NEK3, NEK4, NEK5, NEK6, NEK7, NEK8, NEK9, NEK10, NEK11 | ||
| NKF1 | 3 | SBK, SgK069, SgK110 | ||
| NKF2 | 1 | PINK1 | ||
| NKF4 | 2 | CLIK1, CLIK1L | ||
| PEK | 4 | GCN2, HRI, PEK, PKR | ||
| PLK | 4 | PLK1, PLK2, PLK3, PLK4 | ||
| TLK | 2 | TLK1, TLK2 | ||
| TOPK | 1 | PBK | ||
| TTK | 1 | TTK | ||
| ULK | 4 | Fused, ULK1, ULK2, ULK3 | ||
| VPS15 | 1 | PIK3R4 | ||
| WEE | 3 | MYT1, Wee1, Wee1B | ||
| Wnk | 4 | Wnk1, Wnk2, Wnk3, Wnk4 | ||
| Other-Unique | 2 | KIS, SgK496 |