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Table 2 The 428 human ePKs with known or likely kinase catalytic function

From: Genomic analysis of the eukaryotic protein kinase superfamily: a perspective

Group Number within group Family Number within family Family members (SUGEN nomenclature)
TK 84 Ack 2 ACK, TNK1
   Abl 2 ABL, ARG
   Csk 2 CSK, CTK
   FAK 2 FAK, PYK2
   Fer 2 FER, FES
   JAK 4 JAK1, JAK2, JAK3, TYK2
   Src 11 BLK, BRK, FGR, FRK, FYN, HCK, LCK, LYN, SRC, SRM, YES
   Syk 2 SYK, ZAP70
   Tec 5 BMX, BTK, ITK, TEC, TXK
   Alk 2 ALK, LTK
   Axl 3 AXL, MER, TYRO3
   DDR 2 DDR1, DDR2
   EGFR 3 EGFR, HER2/ErbB2, HER4/ErbB4
   Eph 12 EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphB1, EphB2, EphB3, EphB4
   FGFR 4 FGFR1, FGFR2, FGFR3, FGFR4
   InsR 3 IGF1R, INSR, IRR
   Lmr 3 LMR1, LMR2, LMR3
   Met 2 MET, RON
   Musk 1 MUSK
   PDGFR/VEGFR 8 FLT3, FMS, KIT, PDGFRa, PDGFRb, FLT1, FLT4, KDR
   Ret 1 RET
   Ror 2 ROR1, ROR2
   Sev 1 ROS
   Tie 2 TIE1, TIE2
   Trk 3 TRKA, TRKB, TRKC
AGC 61 PKA 5 PKACa, PKACb, PKACg, PRKX, PRKY
   PKG 2 PKG1, PKG2
   PKC 9 PKCa, PKCb, PKCd, PKCe, PKCg, PKCh, PKCi, PKCt, PKCz
   AKT 3 AKT1, AKT2, AKT3
   DMPK 7 CRIK, DMPK1, DMPK2, MRCKa, MRCKb, ROCK1, ROCK2
   GRK 7 BARK1, BARK2, GPRK4, GPRK5, GPRK6, GPRK7, RHOK
   MAST 5 MAST1, MAST2, MAST3, MAST4, MASTL
   NDR 4 LATS1, LATS2, NDR1, NDR2
   PKB 1 PDK1
   PKN 3 PKN1, PKN2, PKN3
   RSK 9 MSK1, MSK2, RSK1, RSK2, RSK3, RSK4, SgK494, p70S6K, p70S6Kb
   SGK 3 SGK, SGK2, SGK3
   YANK 3 YANK1, YANK2, YANK3
CAMK 66 CAMK1 5 CaMK1a, CaMK1b, CaMK1d, CaMK1g, CaMK4
   CAMK2 4 CaMK2a, CaMK2b, CaMK2d, CaMK2g
   CAMKL 20 AMPKa1, AMPKa2, BRSK1, BRSK2, CHK1, HUNK, LKB1, MARK1, MARK2, MARK3, MARK4, MEL, NIM1, NuaK1, NuaK2, PASK, QIK, QSK, SIK, SNRK
   DAPK 5 DAPK1, DAPK2, DAPK3, DRAK1, DRAK2
   DCAMKL 3 DCAMKL1, DCAMKL2, DCAMKL3
   MAPKAPK 5 MAPKAPK2, MAPKAPK3, MAPKAPK5, MNK1, MNK2
   MLCK 4 caMLCK, skMLCK, smMLCK, SgK085
   PHK 2 PHKg1, PHKg2
   PIM 3 PIM1, PIM2, PIM3
   PKD 3 PKD1, PKD2, PKD3
   PSK 1 PSKH1
   RAD53 1 CHK2
   Trio 4 Obscn, SPEG, Trad, Trio
   TSSK 5 SSTK, TSSK1, TSSK2, TSSK3, TSSK
   CAMK-Unique 1 STK33
CMGC 61 CDK 20 CCRK, CDC2, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CHED, CRK7, PCTAIRE1, PCTAIRE2, PCTAIRE3, PFTAIRE1, PFTAIRE2, PITSLRE
   MAPK 14 Erk1, Erk2, Erk3, Erk4, Erk5, Erk7, JNK1, JNK2, JNK3, NLK, p38a, p38b, p38d, p38g
   GSK 2 GSK3A, GSK3B
   CLK 4 CLK1, CLK2, CLK3, CLK4
   CDKL 5 CDKL1, CDKL2, CDKL3, CDKL4, CDKL5
   DYRK 10 DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4, HIPK1, HIPK2, HIPK3, HIPK4, PRP4
   RCK 3 ICK, MAK, MOK
   SRPK 3 MSSK1, SRPK1, SRPK2
STE 45 STE7 7 MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7
   STE20 28 GCK, HPK1, KHS1, KHS2, LOK, MST1, MST2, MST3, MST4, MYO3A, MYO3B, OSR1, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, SLK, STLK3, TAO1, TAO2, TAO3, YSK1, ZC1/HGK, ZC2/TNIK, ZC3/MINK, ZC4/NRK
   STE11 8 MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8
   STE-Unique 2 COT, NIK
TKL 37 IRAK 2 IRAK1, IRAK4
   LISK 4 LIMK1, LIMK2, TESK1, TESK2
   LRRK 2 LRRK1, LRRK2
   MLK 9 DLK, HH498, LZK, MLK1, MLK2, MLK3, MLK4, TAK1, ZAK
   RAF 3 ARAF, BRAF, RAF1
   RIPK 5 ANKRD3, RIPK1, RIPK2, RIPK3, SgK288
   STKR 12 ACTR2, ACTR2B, ALK1, ALK2, ALK4, ALK7, BMPR1A, BMPR1B, BMPR2, MISR2, TGFbR1, TGFbR2
CK1 11 CK1 7 CK1a, CK1a2, CK1d, CK1e, CK1g1, CK1g2, CK1g3
   TTBK 2 TTBK1, TTBK2
   VRK 2 VRK1, VRK2
Other 63 Aur 3 AurA, AurB, AurC
   BUB 1 BUB1
   Bud32 1 PRPK
   CAMKK 2 CaMKK1, CaMKK2
   CDC7 1 CDC7
   CK2 2 CK2a1, CK2a2
   IKK 4 IKKa, IKKb, IKKe, TBK1
   IRE 2 IRE1, IRE2
   MOS 1 MOS
   NAK 4 AAK1, BIKE, GAK, MPSK1
   NEK 11 NEK1, NEK2, NEK3, NEK4, NEK5, NEK6, NEK7, NEK8, NEK9, NEK10, NEK11
   NKF1 3 SBK, SgK069, SgK110
   NKF2 1 PINK1
   NKF4 2 CLIK1, CLIK1L
   PEK 4 GCN2, HRI, PEK, PKR
   PLK 4 PLK1, PLK2, PLK3, PLK4
   TLK 2 TLK1, TLK2
   TOPK 1 PBK
   TTK 1 TTK
   ULK 4 Fused, ULK1, ULK2, ULK3
   VPS15 1 PIK3R4
   WEE 3 MYT1, Wee1, Wee1B
   Wnk 4 Wnk1, Wnk2, Wnk3, Wnk4
   Other-Unique 2 KIS, SgK496