Figure 6

Plots of the AEA parameter versus linkage disequilibrium (LD) for all pairs of SNPs. The apparent relative risk for all marker SNPs (when paired with a hypothetical disease SNP of relative risk = 10) is plotted on a log₁₀ scale against measures of LD in (a,c,e) the Gambian and (b,d,f) the Malawian populations. The AEA parameter is plotted against (a,b) r², (c,d) D, and (e,f) D'. The correlation coefficient (r) between the AEA parameter and the measure of LD is indicated on each graph.