Protein* | KLF number | Species | Chromosomal localization† | Transcriptional activity (and functional domains) | Expression pattern | Interacting coactivatorand/or corepressor | Cellular functions |
---|---|---|---|---|---|---|---|
Sp1 | - | Human, mouse, rat and Drosophila | 12q13 | Activator (Q-rich domains) | Ubiquitous | CRSP, p300/CBP, TAFII130 | Embryogenesis |
Sp2 | - | Human, mouse and rat | 17q21 | Unknown (Q-rich domain) | Unknown | Unknown | |
Sp3 | - | Human, mouse and rat | 2q31 | Activator and/or repressor (Q-rich domains) | Ubiquitous | Unknown | Unknown |
Sp4 | - | Human, mouse and rat | 7p15 | Activator (Q-rich domains) | Brain-enriched | Unknown | Post-natal survival and male fertility |
mSp5 | - | Mouse | Unknown | Ubiquitous | Unknown | Unknown | |
Sp6 | KLF14 | Human and mouse | 17q21 | Activator | Ubiquitous | Unknown | Unknown |
EKLF | KLF1 | Human and mouse | 19p13 | Activator (acidic domain) | Erythroid and mast cells | p300/CBP, PCAF, SWI/SNF and mSin3A | Erythropoiesis |
LKLF | KLF2 | Human and mouse | 19p13 | Activator (acidic domain) | Lung, blood vessels, lymphocytes | Unknown | Blood vessel, lung development, T-cell survival |
BKLF | KLF3 | Human, mouse and rat | 4p14 | Activator/repressor (PVDLS/T motif) | Erythroid tissue- and brain-enriched | CtBP2 | Unknown |
GKLF | KLF4 | Human, mouse, rat and zebrafish | 9q31 | Activator and/or repressor (acidic domain) | Gut-enriched | p300/CBP | Anti-proliferation, survival |
IKLF | KLF5 | Human, mouse and rat | 13q21 | Activator | Gut and epithelial tissues | Unknown | Cell growth |
CPBP | KLF6 | Human and mouse | 10p15 | Activator | Ubiquitous | Unknown | Putative tumor suppressor |
UKLF | KLF7 | Human and mouse | 2q32 | Activator (acidic domain) | Ubiquitous | Unknown | Cell-cycle arrest |
BKLF3 | KLF8 | Human | Xp11 | Repressor (PVDLS/T motif) | Ubiquitous | CtBP2 | Unknown |
BTEB1 | KLF9 | Human, mouse and rat | 9q13 | Activator/repressor (SID) | Ubiquitous | mSin3A | Neurite outgrowth and carcinogen metabolism |
TIEG1 | KLF10 | Human | 8q22 | Repressor (SID, R2, R3) | Ubiquitous | mSin3A | Apoptosis, anti-proliferation |
TIEG2/FKLF | KLF11 | Human | 2p25 | Activator and/or repressor (SID, R2, R3) | Ubiquitous | mSin3A | Anti-proliferation |
AP-2rep | KLF12 | Human, mouse, rat and zebrafish | 13q21 | Repressor (PVDLS/T motif) | Brain, kidney, liver and lung | CtBP1 | Unknown |
BTEB3/RFLAT-1/FKLF-2 | KLF13 | Human, mouse and rat | 15q12 | Activator/repressor (SID, R2 and R3) | Ubiquitous | mSin3A, p300/CBP and PCAF | Anti-proliferation and carcinogen metabolism |
KKLF | KLF15 | Human, mouse and rat | 3q13 | Repressor | Ubiquitous | Unknown | Unknown |
BTEB4/mDRRF | KLF16 | Human and mouse | 19q13 | Repressor (SID) | Ubiquitous | mSin3A | Carcinogen metabolism |
BTEB5 | - | Human | 7 | Unknown | Unknown | Unknown | Unknown |