Skip to main content

Table 1 Summary of the functional features of Sp1-like/KLF family members

From: Sp1- and Krüppel-like transcription factors

Protein*

KLF number

Species

Chromosomal localization

Transcriptional activity (and functional domains)

Expression pattern

Interacting coactivatorand/or corepressor

Cellular functions

Sp1

-

Human, mouse, rat and Drosophila

12q13

Activator (Q-rich domains)

Ubiquitous

CRSP, p300/CBP, TAFII130

Embryogenesis

Sp2

-

Human, mouse and rat

17q21

Unknown (Q-rich domain)

 

Unknown

Unknown

Sp3

-

Human, mouse and rat

2q31

Activator and/or repressor (Q-rich domains)

Ubiquitous

Unknown

Unknown

Sp4

-

Human, mouse and rat

7p15

Activator (Q-rich domains)

Brain-enriched

Unknown

Post-natal survival and male fertility

mSp5

-

Mouse

 

Unknown

Ubiquitous

Unknown

Unknown

Sp6

KLF14

Human and mouse

17q21

Activator

Ubiquitous

Unknown

Unknown

EKLF

KLF1

Human and mouse

19p13

Activator (acidic domain)

Erythroid and mast cells

p300/CBP, PCAF, SWI/SNF and mSin3A

Erythropoiesis

LKLF

KLF2

Human and mouse

19p13

Activator (acidic domain)

Lung, blood vessels, lymphocytes

Unknown

Blood vessel, lung development, T-cell survival

BKLF

KLF3

Human, mouse and rat

4p14

Activator/repressor (PVDLS/T motif)

Erythroid tissue- and brain-enriched

CtBP2

Unknown

GKLF

KLF4

Human, mouse, rat and zebrafish

9q31

Activator and/or repressor (acidic domain)

Gut-enriched

p300/CBP

Anti-proliferation, survival

IKLF

KLF5

Human, mouse and rat

13q21

Activator

Gut and epithelial tissues

Unknown

Cell growth

CPBP

KLF6

Human and mouse

10p15

Activator

Ubiquitous

Unknown

Putative tumor suppressor

UKLF

KLF7

Human and mouse

2q32

Activator (acidic domain)

Ubiquitous

Unknown

Cell-cycle arrest

BKLF3

KLF8

Human

Xp11

Repressor (PVDLS/T motif)

Ubiquitous

CtBP2

Unknown

BTEB1

KLF9

Human, mouse and rat

9q13

Activator/repressor (SID)

Ubiquitous

mSin3A

Neurite outgrowth and carcinogen metabolism

TIEG1

KLF10

Human

8q22

Repressor (SID, R2, R3)

Ubiquitous

mSin3A

Apoptosis, anti-proliferation

TIEG2/FKLF

KLF11

Human

2p25

Activator and/or repressor (SID, R2, R3)

Ubiquitous

mSin3A

Anti-proliferation

AP-2rep

KLF12

Human, mouse, rat and zebrafish

13q21

Repressor (PVDLS/T motif)

Brain, kidney, liver and lung

CtBP1

Unknown

BTEB3/RFLAT-1/FKLF-2

KLF13

Human, mouse and rat

15q12

Activator/repressor (SID, R2 and R3)

Ubiquitous

mSin3A, p300/CBP and PCAF

Anti-proliferation and carcinogen metabolism

KKLF

KLF15

Human, mouse and rat

3q13

Repressor

Ubiquitous

Unknown

Unknown

BTEB4/mDRRF

KLF16

Human and mouse

19q13

Repressor (SID)

Ubiquitous

mSin3A

Carcinogen metabolism

BTEB5

-

Human

7

Unknown

Unknown

Unknown

Unknown

  1. *Original name with which the protein was first published. Chromosomal localization data refer to the human genes and have been obtained from the human genome database of the National Center for Biotechnology Information (NCBI) [57].