Figure 3
Global concordance between the oligo- and cDNA-array gene-expression databases after UniGene matching. (a) Correlation of correlations (rc) and number of genes remaining in the dataset as a function of the correlation cutoff value. For the original cDNA- and oligo-array sets before UniGene matching, rc for the cells was only 0.48. (b) Cluster trees (average linkage, correlation metric) for the 60 cell lines based on cDNA array and oligo databases after UniGene matching and correlation screening at a threshold value of r = 0.3 (which produced sets of 1,733 cDNA-array and 1,564 oligo-array transcripts). Most of the clusters are very similar to each other in the two trees, and the clusters for five tissues of origin were found almost identical: CNS (red), renal (green), melanoma (purple), leukemia (pink), and colon (blue).