Figure 1

Temporal events in mouse prostate development. Androgen levels (solid line) rise beginning at day E12, fall shortly after birth, and rise again at puberty [65]. Branching morphogenesis (dashed line) begins at approximately day E17 with prostate budding, peaks at approximately day 10 (after birth), and is essentially complete before puberty by day 35 [23]. Peak DNA synthesis (dotted line), representing the development of the prostate epithelial and stromal cell mass, occurs at approximately day 35 [66]. cDNA libraries were constructed from prostate tissues obtained at defined points of prostate development (stars).