From: Identifying biological themes within lists of genes with EASE
 | Total time for analysis | Themes of genes downregulated with caloric restriction | Themes of genes upregulated with caloric restriction | Themes of genes downregulated with aging | Themes of genes upregulated with aging |
---|---|---|---|---|---|
Manual analysis by Kayo et al. [24] | Approximately 200 hours | Energy metabolism, mitochondrial bioenergetics | Structural proteins, cytoskeletal proteins | Energy metabolism, mitochondrial electron transport, oxidative phosphorylation | [Inflamation/immune function], [oxidative stress] |
EASE | Approximately 15 minutes | Mitochondrion, electron transport, mitochondrial membrane, inner membrane, primary active transporter, mitochondrial electron transport chain, oxidoreductase, hydrogen ion transporter, mitochondrial inner membrane, monovalent inorganic cation transporter, energy pathways, [carrier], ion transporter, [cytoplasm] | Extracellular matrix, [calmodulin binding], [morphogenesis], structural molecule, [development], microfibril, cytoskeleton | Inner membrane, hydrogen ion transporter, [intracellular], monovalent inorganic cation transporter, metabolism, mitochondrial membrane, mitochondrial inner membrane, primary active transporter, energy pathways, mitochondrion, ion transporter, [carrier], cation transporter | [Gas transport], [oxygen transport] |