Figure 2

Regulograms of Myc targets analyzed by genomic sequence comparison and ChIP. Human and mouse sequences are aligned in each regulogram which depicts in colored regions the sequences with greater than 50% identity. Within these regions, the percentage of sequence identity is represented on the top line and the number of conserved transcription factor binding site 'hits' is represented by the bottom line. The genomic region analyzed by ChIP is mapped below each regulogram. Red boxes represent exons, with the first box always being exon 1. Vertical bars with asterisks indicate locations of conserved canonical E-boxes (5'-CACGTG-3'). Blue bars under each map represent fragments analyzed by ChIP. Ex, exon.