Table 4 Candidate ocular disease genes identified in three mouse retina/eye cDNA libraries
From: Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina
Disease | Location | Number of ESTs in interval | Number of unique genes | Example accession number | Gene name |
AA | 11p15 | 60 | 19 | NM_015814 | Dickkopf homolog 3 (Xenopus laevis) |
ARMD1 | 1q25-q31 | 17 | 8 | BC023001 | Regulator of G-protein signaling 2 |
AXPC1 | 1q31-q32 | 18 | 9 | NM_008131 | Glutamine synthetase (Glns) |
BBS5 | 2q31 | 8 | 4 | AK019448 | Procollagen, type III, alpha 1 |
BCD | 4q35-qter | 2 | 1 | U27315 | Adenine nucleotide translocase-1 (Ant1) |
CACD | 17p13 | 26 | 16 | BC008093 | Eukaryotic translation initiation factor 5A |
COD2, XLPCD | Xq27 | 2 | 1 | NM_008031 | Fragile X mental retardation syndrome 1 homolog (Fmr1) |
CORD1 | 18q21.1-q21.3 | 2 | 1 | NM_009190 | Vacuolar protein sorting 4b (yeast) |
CORD7 | 6q | 83 | 29 | NM_007865 | Delta-like 1 (Drosophila) |
CORD8 | 1q12-q24 | 30 | 20 | NM_011342 | SEC22 vesicle trafficking protein-like 1 (S. cerevisiae) |
CORD9 | 8p11 | 5 | 3 | NM_031158 | Ankyrin 1, erythroid |
CYMD | 7p21-p15 | 20 | 10 | AK002910 | Chromobox homolog 3 (Drosophila HP1 gamma) |
EVR3 | 11p13-p12 | 9 | 6 | NM_013627 | Paired box gene 6 (Pax6) |
LCA3 | 14q24 | 11 | 8 | NM_007701 | C. elegans ceh-10 homeo domain containing homolog |
LCA5 | 6q11-q16 | 45 | 6 | NM_009945 | Cytochrome c oxidase, subunit VIIa 3 (Cox7a3) |
MCDR1 | 6q14-q16.2 | 41 | 4 | AK019500 | NS1-associated protein 1 |
MRST | 15q24 | 12 | 6 | NM_024431 | Testis expressed gene 189 |
OPA2 | Xp11.4-p11.2 | 26 | 10 | NM_009457 | Ubiquitin-activating enzyme E1, Chr X |
PRD | Xp11.3-p11.23 | 19 | 8 | NM_013680 | Synapsin I |
RCD1 | 6q25-q26 | 8 | 3 | AF147785 | Zinc finger protein ZAC1 (Zac1) |
RNANC | 10q21 | 3 | 2 | X16461 | Cell division cycle 2 homolog A (S. pombe) |
RP17 | 17q22 | 10 | 4 | NM_009296 | Suppressor of Ty 4 homolog (S. cerevisiae) |
RP22 | 16p12.1-p12.3 | 6 | 4 | NM_007672 | Cerebellar degeneration-related 2 |
RP24 | Xq26-q27 | 4 | 2 | NM_016697 | Glypican 3 |
RP25 | 6cen-q15 | 45 | 6 | NM_009945 | Cytochrome c oxidase, subunit VIIa 2 |
RP26 | 2q31-q33 | 142 | 20 | NM_022988 | Ngg1 interacting factor 3-like 1 (S. pombe) |
RP28 | 2p11-p16 | 26 | 17 | NM_009837 | Chaperonin subunit 4 (delta) (Cct4) |
RP29 | 4q32-q34 | 4 | 3 | NM_025436 | Sterol-C4-methyl oxidase-like (Sc4mol) |
STGD4 | 4p | 9 | 7 | NM_013457 | Adducin 1 (alpha) |
USH1A, USH1 | 14q32 | 13 | 6 | NM_020494 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 13 (RNA helicase A) |
USH1E | 21q21 | 2 | 1 | BC013562 | Similar to E4tf1-60 transcription factor |
USH1G | 17q24-q25 | 39 | 26 | AK012619 | SMT3 (supressor of mif two, 3) homolog 2 (S. cerevisiae) |
USH2B | 3p24.2-p23 | 4 | 3 | NM_009455 | Ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast) |
USH2C | 5q14-q21 | 7 | 5 | NM_010151 | Nuclear receptor subfamily 2, group F, member 1 |
VRNI | 11q13 | 45 | 24 | NM_023131 | Ras and a-factor-converting enzyme 1 homolog (S. cerevisiae) (Rce1) |
WFS2 | 4q22-q24 | 13 | 9 | NM_007917 | Eukaryotic translation initiation factor 4E (Eif4e) |
WGN1, ERVR | 5q13-q14 | 13 | 9 | AY037837 | Single-stranded DNA binding protein 2 |