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Table 1 MAPPFinder analysis

From: Time- and exercise-dependent gene regulation in human skeletal muscle

Upregulated process

 

C

M

T

Z

Downregulated process

C

M

T

Z

6 hours after RE

Circadian rhythm

4

10

13

7.2

Oxygen transport

3

8

17

4.5

 

Nucleic acid metabolism

59

1570

2905

2.7

Calcium ion transport

8

44

67

4.4

 

Hearing

3

32

54

2.3

DNA repair

16

134

195

4.2

 

G2/M transition of mitotic cell cycle

3

34

40

2.2

Regulation of translational initiation

5

26

30

3.6

 

Anti-apoptosis

4

53

71

2.1

Di-, trivalent inorganic cation transport

8

66

102

3.0

 

Transcription

38

1025

1992

2.0

Glycogen metabolism

4

24

25

2.9

18 hours after RE

Protein amino acid phosphorylation

60

383

735

4.7

Peripheral nervous system development

5

11

12

5.5

 

Regulation of cell cycle

42

248

294

4.5

Glycosphingolipid biosynthesis

3

5

5

5.0

 

Anti-apoptosis

12

53

71

3.5

Antigen processing, endogenous antigen via MHC class I

3

6

11

4.5

 

Mitochondrion organization and biogenesis

5

15

23

3.3

Iron transport

4

10

21

4.5

 

Protein-mitochondrial targeting

4

11

19

3.2

Glutamine family amino acid catabolism

4

13

19

3.7

 

L-Amino-acid transport

3

7

9

3.1

Male gonad development

3

9

12

3.4

Diurnal

Regulation of transcription, DNA-dependent

46

938

1852

3.7

Regulation of protein biosynthesis

3

7

12

5.7

 

Cell differentiation

7

68

109

3.6

Non-selective vesicle transport

7

57

63

3.7

 

Response to stress

24

452

566

3.0

Actin cytoskeleton organization and biogenesis

3

15

23

3.5

 

Hemopoiesis

3

22

28

2.9

Cell-cycle arrest

5

37

53

3.4

 

Oncogenesis

14

253

282

2.4

Main pathways of carbohydrate metabolism

7

69

100

3.1

 

Nucleic acid metabolism

61

1570

2905

2.3

Tricarboxylic acid cycle

3

20

23

2.8

  1. Filtered genes (p < 0.05) were analyzed with MAPPFinder to determine the biological processes that were regulated in each comparison. C, number of genes changed; M, number of genes represented on chip in a process; T, number of genes in the Gene Ontology (GO) process: Z, significance Z-score value. The top six, non-redundant GO terms are shown for each comparison