Figure 1
From: Time- and exercise-dependent gene regulation in human skeletal muscle
Venn diagrams of human genes undergoing diurnal regulation compared to their mouse circadian orthologs. (a) Comparison with mouse circadian gene orthologs reported in [19]; (b) comparison with mouse circadian gene orthologs reported in [20]. In the diurnal comparison (0800 vs 2000 h), 608 human genes were changed significantly (p < 0.05) in the non-exercised leg. An additional statistical filter was applied (p < 0.05 and absolute fold change > 20%) that resulted in a list of 239 diurnally regulated (0800 vs 2000 h) genes, that were compared with the mouse circadian orthologs. Gray shading indicates genes represented in Figure 2. Genes listed to the right of each Venn diagram are the intersection of all three tissues (red numbers). mHrts, mouse ortholog is circadian-regulated in heart [19] (n = 462); mLvrs, mouse ortholog is circadian-regulated in liver [19] (n = 575); mLvrp, mouse ortholog is circadian-regulated in liver [20] (n = 335); mSCNp, mouse ortholog is circadian-regulated in the SCN [20] (n = 337).