Table 3 Known genes differentially expressed in ceramide-dependent apoptosis with no identified direct interaction with the ceramide-dependent apoptosis process

Signal transduction

   yl85b10

1842

H05211

Hs.22003

1.62

0.40

7.99

0.37

4.94

Solute carrier family 6 (neurotransmitter transporter, GABA), member 1

SLC6A1

   yf77g11

3900

R14207; R37490

Hs.75819

1.12

0.12

5.02

0.43

4.46

Glycoprotein M6A

GPM6A

   yg63f10

1552

R26636; R49665

Hs.24212

1.01

0.15

4.02

0.61

3.98

Latrophilin

KIAA0786

   c-2ee07

116218

Z45003

Hs.107979

1.75

0.35

6.17

0.85

3.52

Small membrane protein 1

SMP1

   yf60h11

12653

R13771

Hs.61628

1.43

0.18

4.68

0.61

3.28

Calcium binding atopy-related autoantigen 1

CBARA1

   yf88a09

9668

R15201

Hs.181326

4.01

0.50

11.65

2.01

2.90

Myotubularin-related protein 2

MTMR2

   yg11b08

107475

R17181; R41731

Hs.5462

0.72

0.12

1.54

0.33

2.14

Solute carrier family 4, sodium bicarbonate cotransporter, member 4

SLC4A4

   c-2mh12

1997

Z41050; Z45338

Hs.108787

1.08

0.21

0.52

0.04

0.47

Phosphatidylinositol glycan, class N

PIGN

   yc87e10

115203

F10343; F12737

Hs.173717

1.24

0.17

0.50

0.06

0.40

Phosphatidic acid phosphatase type 2B

PPAP2B

   yf48c10

9043

R12286; R12797

Hs.10842

1.10

0.24

0.43

0.03

0.39

RAN, member RAS oncogene family

RAN

   yd09f12

2991

R39085

Hs.306359

2.39

0.46

0.90

0.22

0.38

Hect domain and RCC1 (CHC1)-like domain (RLD) 1

HERC1

   c-3ie05

5307

F10685; F13091

Hs.9347

1.48

0.24

0.53

0.02

0.36

Regulator of G-protein signaling 14

RGS14

   yg16c08

5294

R17962; R43452

Hs.1440

1.05

0.23

0.29

0.04

0.27

Gamma-aminobutyric acid (GABA) A receptor, beta 3

GABRB3

   yf50c04

1366

R11777; R37698

Hs.5985

1.13

0.12

0.17

0.01

0.15

Non-kinase Cdc42 effector protein SPEC2

LOC56990

Transcription/translation

   yf71g02

5232

R40420

Hs.16313

0.90

0.13

2.30

0.15

2.55

Kruppel-like zinc-finger protein GLIS2

GLIS2

   c-26a02

451

F07446

Hs.13993

1.64

0.38

3.39

0.73

2.07

TBP-like 1

TBPL1

   c-05c07

4917

Z38284; Z41997

Hs.26973

1.21

0.20

2.45

0.52

2.02

Bromodomain adjacent to zinc-finger domain, 2B

BAZ2B

   c-24a11

114423

F07382

Hs.75678

1.38

0.23

0.66

0.16

0.47

FBJ murine osteosarcoma viral oncogene homolog B

FOSB

   yg90e12

10904

R56427; R56428

Hs.239

1.28

0.23

0.59

0.03

0.46

Forkhead box M1

FOXM1

   yf61e03

4401

R13803; R37662

Hs.182447

7.20

1.01

2.75

0.60

0.38

Heterogeneous nuclear ribonucleoprotein C (C1/C2)

HNRPC

   yf64g02

993

R37803

Hs.6151

4.87

0.77

1.87

0.46

0.38

Pumilio homolog 2 (Drosophila)

PUM2

   yg53f10

1678

R62465; R25720

Hs.520

1.41

0.20

ND

ND

0.35

Nuclear receptor subfamily 2, group C, member 2

NR2C2

   yg47e10

1548

R21283; R45373

Hs.14520

1.55

0.26

0.53

0.13

0.34

Eukaryotic translation initiation factor 2C, 1

EIF2C1

   yg36d06

1872

R24568; R44373

Hs.76177

10.91

1.23

3.67

0.10

0.34

Transcription factor CP2

TFCP2

   yg60b12

303

R35123; R49511

Hs.2186

3.12

0.63

0.94

0.07

0.30

Eukaryotic translation elongation factor 1 gamma

EEF1G

   yg27a08

4127

R43968

Hs.278589

9.43

1.24

2.76

0.40

0.29

General transcription factor II, i, pseudogene 1

GTF2IP1

Cellular traffic or structure proteins

   yg19f05

200119

R20424; R43544

Hs.169793

1.51

0.36

7.37

1.32

4.86

Ribosomal protein L32

RPL32

   yc86h03

2760

F12918; T75229

Hs.182625

2.38

0.26

7.78

1.17

3.27

Vamp (vesicle-associated membrane protein)-associated protein B and C

VAPB

   yc87f04

5084

R38549; T75126

Hs.22826

1.83

0.11

5.59

0.64

3.06

Tropomodulin 3 (ubiquitous)

TMOD3

   yf98g01

8512

R18713

Hs.75196

2.96

0.63

9.29

0.80

3.14

Ankyrin repeat-containing protein

G9A

   yh17e09

1304

R59488; R59489

Hs.30991

0.78

0.19

2.32

0.11

2.97

Ankyrin repeat domain 6

ANKRD6

   yf76d11

424

R13426; R40938

Hs.119324

0.84

0.08

2.07

0.35

2.48

Kinesin-like 4

KNSL4

   c-27f03

1382

F07488

Hs.89497

2.32

0.31

5.60

0.64

2.42

Lamin B1

LMNB1

   yc96a12

11155

F13331; T77651

Hs.159613

4.50

0.32

10.84

2.13

2.41

Thyroid hormone receptor binding protein

AIB3

   yf57c11

1225

R12822; r20734

Hs.1501

0.94

0.22

2.25

0.22

2.39

Syndecan 2

SDC2

   yl71a06

10804

H05894

Hs.6682

1.33

0.11

2.94

0.20

2.21

Solute carrier family 7, cationic amino acid transporter, y+ system, member 11

SLC7A11

   yc99f07

11082

T78361

Hs.103042

2.21

0.07

0.98

0.19

0.44

Microtubule-associated protein 1B

MAP1B

   yf72e08

2558

R13080; R40510

Hs.7979

2.05

0.34

0.80

0.15

0.39

Likely ortholog of mouse synaptic vesicle glycoprotein 2a

SV2

   yc87h12

2952

F10545; F12946

Hs.21611

5.68

0.59

1.93

0.17

0.34

Kinesin family member 3C

KIF3C

   yg54d05

604

R25813; R46810

Hs.117977

1.62

0.33

0.50

0.11

0.31

Kinesin 2 (60-70 kD)

KNS2

   yf91b02

1980

R16352; R42300

Hs.103042

3.50

0.41

1.01

0.24

0.29

Microtubule-associated protein 1B

MAP1B

   yf72a03

115963

R13048; R40479

Hs.187958

1.46

0.34

0.40

0.06

0.28

Solute carrier family 6, member 8, accessory proteins BAP31/BAP29

SLC6A8, DXS1357E

Immunity/inflammatory response

   yg75d06

25621

R54423

Hs.179661

1.88

0.18

8.01

1.02

4.26

FK506-binding protein 1A (12 kD)

FKBP1A

   yg65b03

2453

R35324

Hs.9688

0.86

0.13

3.67

0.60

4.26

Leukocyte membrane antigen

IRC1

   yg57f05

190007

R34428

Hs.181244

3.83

0.24

9.76

1.22

2.55

MHC class I gene family

   yf51e08

2563

R12005; R39844

Hs.75682

0.89

0.04

2.05

0.21

2.31

Autoantigen

RCD-8

   c-2bh04

190137

F03851; F07604

Hs.284394

1.13

0.07

0.56

0.07

0.50

Complement component 3

C3

   yf59h02

5580

R13549; R20669

Hs.82689

1.05

0.21

0.47

0.10

0.44

Tumor rejection antigen (gp96) 1

TRA1

   yc86g03

8628

F10456; F12856

Hs.302749

1.51

0.35

0.58

0.09

0.39

FK506-binding protein 9 (63 kD)

FKBP9

Protein processing

   yf68a10

1071

R40190;

Hs.75890

0.55

0.13

2.09

0.23

3.80

Site-1 protease (subtilisin-like, sterol-regulated, cleaves sterol regulatory element binding proteins)

S1P

   c-2na07

2001

F04230; F07978

Hs.102

1.01

0.16

0.46

0.10

0.45

Aminomethyltransferase (glycine cleavage system protein T)

AMT

   yc85d05

6301

F10498; F12892

Hs.170197

1.45

0.22

0.59

0.10

0.41

Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

GOT2

   c-2ge12

2793

Z40826; Z46090

Hs.183212

1.14

0.19

0.45

0.09

0.39

Isoprenylcysteine carboxyl methyltransferase

ICMT

   yg52f04

202164

R21082; R46258

Hs.235887

1.55

0.31

0.54

0.08

0.34

HMT1 (hnRNP methyltransferase, Saccharomyces cerevisiae)-like 1

HRMT1L1

Proteases

   yf64f07

2813

R13707; R37801

Hs.171501

1.27

0.24

ND

ND

0.39

Ubiquitin specific protease 11

USP11

Metabolism

   yc97f08

1805

R39698; T78043

Hs.2838

2.73

0.24

9.35

0.86

3.42

Malic enzyme 3, NADP(+)-dependent, mitochondrial

ME3

   yg97d06

3929

R59198; R59256

Hs.78989

0.68

0.07

1.99

0.18

2.94

Alcohol dehydrogenase 5 (class III), chi polypeptide

ADH5

   c-2ca07

1549

F03858; F07608

Hs.180616

1.04

0.12

0.50

ND

0.48

CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1

CD36L1

   yc95g06

3164

R39463; T77281

Hs.155247

1.01

0.20

0.31

0.05

0.30

Aldolase C, fructose-bisphosphate

ALDOC

Miscellaneous

   yg24g06

3097

R19249; R44514

Hs.22654

0.48

0.08

2.93

0.67

6.12

Sodium channel, voltage-gated, type I, alpha polypeptide

SCNIA

   yc89d05

10816

F10796; F13191

Hs.12365

1.26

0.20

5.46

0.36

4.34

Synaptotagmin XIII

SYT13

   c-28e05

4334

F07514

Hs.6126

2.04

0.50

7.19

1.11

3.52

Mannosidase, beta A, lysosomal-like

MANBAL

   yg35g09

4463

R20330

Hs.88764

3.30

0.19

9.88

2.40

2.99

Male-specific lethal-3 (Drosophila)-like 1

MSL3L1

   yg36c01

292

R24560; R44360

Hs.6430

1.50

0.22

4.40

0.78

2.93

Protein with polyglutamine repeat; calcium (Ca²⁺) homeostasis endoplasmic reticulum protein

ERPROT213-21

   yc98a06

1475

R37847; T78111

Hs.301789

1.55

0.27

4.52

0.35

2.92

Capping protein (actin filament) muscle Z-line, alpha 1

CAPZA

   yf54h02

924

R11969

Hs.4865

1.41

0.17

3.05

0.18

2.17

Voltage-gated sodium channel beta-3 subunit (scn3b gene)

HSA243396

   yf91a04

434

R16348; R42296

Hs.12152

1.00

0.24

2.03

0.16

2.04

APMCF1 protein

APMCF1

   c-1ia09

4199

Z39718; Z43661

Hs.8834

0.64

0.15

1.30

0.19

2.02

Ring finger protein 3

RNF3

   yg83b04

4211

R53332; R53937

Hs.7022

1.19

0.28

0.59

0.09

0.50

Dedicator of cytokinesis 3

DOCK3

   yf57d02

4610

R12627; R20528

Hs.334688

1.51

0.25

0.75

0.13

0.50

Phytanoyl-CoA hydroxylase interacting protein

PHYHIP

   yg36h06

3087

R24595; R44400

Hs.7122

1.08

0.13

ND

ND

0.46

Scrapie responsive protein 1

SCRG1

   yf99b05

2822

R18211; R42149

Hs.79284

1.07

0.21

0.48

0.07

0.45

Mesoderm specific transcript (mouse) homolog

MEST

   c-24h06

92359

Z40467; Z44591

Hs.171545

1.02

0.20

0.45

0.11

0.44

HIV-1 Rev binding protein

HRB

   yd05d01

2346

R38832; T80384

Hs.13493

1.06

0.24

0.44

0.06

0.42

Like mouse brain protein E46

E46L

   yf74e11

2106

R13277; R40723

Hs.334851

1.95

0.41

0.80

0.17

0.41

LIM and SH3 protein 1

LASP1

   yd01e11

3181

T78746

Hs.168640

1.17

0.27

0.47

0.10

0.40

Homolog of mouse Ank

ANK

   yf48e09

414

R12292; R12804

Hs.21050

1.22

0.26

0.47

0.07

0.38

g20 protein

LOC51161

   yg16d07

1087

R43459; R17969

Hs.87125

9.91

2.06

3.35

0.51

0.34

EH-domain containing 3

EHD3

   yf57d07

12763

R12632; R20533

Hs.109706

1.78

0.23

0.58

0.09

0.33

Hematological and neurological expressed I

HN1

   c-2Ia12

200991

F04056; F07796

Hs.74376

1.00

0.07

0.33

0.01

0.33

Olfactomedin related ER localized protein

NOE1

   yf61b05

1882

R13783; R37641

Hs.297743

2.04

0.16

0.63

0.12

0.31

Carbonic anhydrase X

CA10

   yf61a10

3960

R39112; R13989

Hs.2288

12.49

1.82

3.38

0.84

0.27

Visinin-like 1

VSNL1

   yg53b12

8924

R25707; R62451

Hs.169047

2.34

0.46

0.54

0.12

0.23

Chondroitin sulfate proteoglycan 3 (neurocan)

CSPG3