Figure 3

Multiple sequence alignment of the polyamine oxidase domain. Amino-acid residues are colored at 100% consensus. The protein designations, coloring scheme and consensus abbreviations are as described in Figure 1; +, acidic residues. The crystal-structure-derived secondary-structure assignments are shown above the alignment with positions involved in cofactor or substrate binding marked by an asterisk. Inserts in individual sequences are given as brown numbers. Species abbreviations: At, A. thaliana; Ce, C. elegans; Dm, D. melanogaster; Hs, Homo sapiens; Mm, Mus musculus; Mtu, Mycobacterium tuberculosis; Rn, Rattus norvegicus; Sp, S. pombe; Zma, Z. mays.