MAP kinase phosphatases

Table 1 Classification and chromosomal and subcellular localization of DUSP genes

DUSP	Subgroup	Human protein	Species ortholog	Chromosomal localization	Subcellular localization	References
DUSP1	I	hVH1/CL100	MKP-1/3CH134 (m)	5q35	Nuclear	[8,60,61,62]
DUSP2	I	hPAC-1	---	2p11.2-2q11	Nuclear	[10,42,62]
DUSP4	I	hVH2/TYP1	MKP-2 (r)	8p12-p11	Nuclear	[42,63,64,65]
DUSP5	I	hVH3/B23	Cpg21 (r)	10q25	Nuclear	[48,62,66]
DUSP6	II	PYST1	MKP-3/rVH6 (r)	12q22-q23	Cytosolic	[49,50,51,65]
DUSP7	II	PYST2/B59	MKP-X (r)	3p21	Cytosolic	[49,51,65,67]
DUSP8	III	hVH5	M3/6 (m)	11p15.5	Nuclear /cytosolic	[13,43,44]
DUSP9	II	MKP-4	---	Xq28	Nuclear /cytosolic	[45]
DUSP10	II(?)	MKP-5	---	1q32	Nuclear /cytosolic	[46,52]
DUSP16	III	MKP-7	MKP-M (m)	12p12	Cytosolic	[14,15,36]

Compilation of DUSP genes identified in the human and other mammalian genomes. The DUSPs are classified into subgroups I, II or III (see text for details). The various alternative names for each gene in human (h) or rat (r) or mouse (m) are given. The chromosomal location of each gene and the subcellular localization of the protein product of each gene are also indicated. Multiple names are used in the literature for each member of the MAP kinase phosphatase gene family. To avoid confusion in this article, we have used the gene names recommended by the human gene nomenclature committee, which uses the root DUSP (for dual specificity phosphatase). Note that the designation of DUSP16 is provisional.

ISSN: 1474-760X