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Table 1 Classification and chromosomal and subcellular localization of DUSP genes

From: MAP kinase phosphatases

DUSP Subgroup Human protein Species ortholog Chromosomal localization Subcellular localization References
DUSP1 I hVH1/CL100 MKP-1/3CH134 (m) 5q35 Nuclear [8,60,61,62]
DUSP2 I hPAC-1 --- 2p11.2-2q11 Nuclear [10,42,62]
DUSP4 I hVH2/TYP1 MKP-2 (r) 8p12-p11 Nuclear [42,63,64,65]
DUSP5 I hVH3/B23 Cpg21 (r) 10q25 Nuclear [48,62,66]
DUSP6 II PYST1 MKP-3/rVH6 (r) 12q22-q23 Cytosolic [49,50,51,65]
DUSP7 II PYST2/B59 MKP-X (r) 3p21 Cytosolic [49,51,65,67]
DUSP8 III hVH5 M3/6 (m) 11p15.5 Nuclear /cytosolic [13,43,44]
DUSP9 II MKP-4 --- Xq28 Nuclear /cytosolic [45]
DUSP10 II(?) MKP-5 --- 1q32 Nuclear /cytosolic [46,52]
DUSP16 III MKP-7 MKP-M (m) 12p12 Cytosolic [14,15,36]
  1. Compilation of DUSP genes identified in the human and other mammalian genomes. The DUSPs are classified into subgroups I, II or III (see text for details). The various alternative names for each gene in human (h) or rat (r) or mouse (m) are given. The chromosomal location of each gene and the subcellular localization of the protein product of each gene are also indicated. Multiple names are used in the literature for each member of the MAP kinase phosphatase gene family. To avoid confusion in this article, we have used the gene names recommended by the human gene nomenclature committee, which uses the root DUSP (for dual specificity phosphatase). Note that the designation of DUSP16 is provisional.