  
Power

Rate of false positives

RMS bias (×10^{2})


(%)

f

q

Naive

NoSeCoLoR

Naive

NoSeCoLoR

5th percentile

95th percentile


10

1.5

0

0.312

0.346

1.577

0.890

0.933

1.669

10

1.5

1

0.130

0.342

0.775

0.784

16.536

17.763

10

2.5

0

0.982

0.939

1.482

0.970

1.474

3.447

10

2.5

1

0.683

0.939

0.749

0.855

15.740

17.271

20

1.5

0

0.313

0.345

1.600

0.878

0.930

2.091

20

1.5

1

0.128

0.324

0.784

0.803

16.320

17.722

20

2.5

0

0.983

0.905

1.560

1.367

3.113

5.967

20

2.5

1

0.685

0.909

0.751

1.078

15.299

16.821

 The proportion, , among all genes of those for which the expression level has been changed is either 10% or 20%. The ratio, f, of treated expression level to mean control expression level is varied between 1.5 and 2.5. The bias multiplier q is either zero (no bias) or 1 (bias as measured in the analysis of the real data). The power is the mean number of correct discriminations achieved in the test divided by the number of true changes (59 and 119 for = 10% and = 20%, respectively). The falsepositive score is the mean number of incorrect discriminations divided by the expected number at the nominal typeI error rate of 0.01. The expected number of false positives is 5.4 when = 10% and 4.8 when = 20%. The RMS bias is computed from the bias as estimated as described in the text. Reported here are the 5th and 95th percentiles over the simulated datasets.