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Table 1 Allele frequency differentiation of drug metabolizing enzymes on the basis of "genetic clusters" versus "racial groups," from the data of Wilson et al. [2]

From: Categorization of humans in biomedical research: genes, race and disease

  Genetic clusters Racial groups
  Allele frequencies σ2 Allele frequencies σ2
Locus C A B D   African Caucasian East Asian  
CYP1A2 0.60 0.66 0.69 0.59 0.0023 0.58 0.68 0.67 0.0030
GSTM1 0.31 0.47 0.53 0.45 0.0087 0.33 0.49 0.52 0.0104
CYP2C19 0.27 0.09 0.37 0.25 0.0134 0.22 0.08 0.354 0.0182
DIA4 0.19 0.22 0.11 0.53 0.0340 0.21 0.21 0.32 0.0040
NAT2 0.46 0.74 0.17 0.33 0.0582 0.58 0.74 0.15 0.0931
CYP2D6 0.70 0.53 0.39 0.42 0.0197 0.70 0.49 0.37 0.0279
  1. Genetic clusters: C, primarily African; A, primarily Caucasian; B, primarily Pacific Islander; D, primarily East Asian. Racial groups: East Asian denotes Chinese plus Papua New Guinean.