From: Focusing on the genetics of hearing: you ain't heard nothin' yet
Class of protein | Specific proteins and genes |
---|---|
Myosins | Myosin VI (MYO6), myosin VIIA (MYO7A), myosin XV (MYO15), and non-muscle myosin heavy chain gene 9 (MYH9) |
Non-myosin cytoskeletal | Diaphanous-1 (HDIA1), Espin (Espn) |
Extracellular matrix | α-tectorin (TECTA), novel protein (COCH), type XI collagen (COL11A2), and otogelin (OTOG) |
Gap junctions/tight junctions | Connexin 26 (GJB2), connexin 30 (GJB6), connexin 31 (GJB3), connexin 43 (GJA1), and claudin-14 (CLDN14) |
Ion channels/transporters | K+ channel (KCNQ4), K+ channel components (KVLQT1 and KCNE1), Na+-K+-Cl- co-transporter (Slc12a2), H+-ATPase B1 subunit (ATP6B1), pendrin (PDS, SLC26A4), and Ca2+ pump (ATP2B2) |
Signaling molecules | Integrin α8β1 (Itga8) |
Transcription factors | Pou domain transcription factors (POU4F3 and POU3F4), and Eyes absent homolog 4 (EYA4) |
Others | Transmembrane serine protease (TMPRSS3) and Wolfram syndrome gene 1 (WFS1) |
Unknown function | Otoferlin(OTOF), novel protein (DFNA5), stereocilin, harmonin, and transmembrane cochlear-expressed gene 1 (TMC1) |