Figure 2

The structure of ADF/cofilins. (a) The three major groups of ADF/cofilins identified in Figure 1 (plants, fungi and vertebrates) are each represented by a structure. The predominant structural features (α helices and β sheets) are shown in colors that correspond to those used in (b), which shows the genomic organization of ADF/cofilins superimposed on the amino-acid sequence, with secondary structures highlighted. The red squares or bars indicate the positions of introns interrupting the deduced amino-acid sequences. Red underlining represents the PIP₂/actin-binding site [30].