Figure 7

The impact of mutations in the Gag-Pol polyprotein on protease activity. The letters above the diagram indicate cleavage sites; cleavage at sites E and F release the protease; subsequent cleavage at sites C, A, and B produce mature structural proteins. Regions in Gag that impact protease processing have been defined by deletion analysis (underlined). Specific mutations (indicated by dots), particularly at the sites between nucleocapsid (p7^NC)and p6 or p6^* (depending on the reading frame), can alter the rates of protease processing at different cleavage sites (green circles: our unpublished data; black circles: summary of published data.) For abbreviations see Figure 5.