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Table 7 Correspondence between the functional annotations of predicted genes and of known genes.

From: Evaluation of thresholds for the detection of binding sites for regulatory proteins in Escherichia coliK12 DNA

Regulon

Consensus/Patser

Dyad-analysis/sweeping

 

Percent with related function

Percent without functional annotation

Percent with related function

Percent without functional annotation

AraC

73.33 (66.67)

37.50 (42.86)

53.75 (51.32)

36.51 (37.70)

ArcA

72.61 (70.75)

45.86 (47.50)

74.07 (70.83)

40.88 (43.75)

ArgR

100.00 (100.00)

18.18 (33.33)

56.25 (36.36)

51.52 (60.71)

CRP

93.90 (93.38)

40.87 (43.63)

-

-

CysB

56.78 (56.56)

43.03 (43.16)

-

-

CytR

53.90 (53.58)

38.56 (38.72)

-

-

FIS

45.52 (45.11)

41.23 (41.28)

-

-

FNR

82.85 (81.99)

45.85 (47.06)

83.77 (83.43)

41.43 (41.92)

FruR

51.96 (51.29)

36.57 (36.89)

-

-

IHF

80.95 (80.33)

46.34 (47.14)

-

-

LexA

69.70 (61.54)

42.11 (48.00)

65.79 (58.06)

38.71 (43.64)

Lrp

82.61 (81.95)

43.67 (44.58)

-

-

NarL

73.38 (72.11)

45.20 (46.35)

-

-

PurR

95.24 (92.31)

8.70 (7.14)

77.14 (70.37)

22.22 (25.00)

TrpR

85.71 (50.00)

30.00 (60.00)

46.94 (40.91)

42.35 (45.00)

TyrR

69.23 (50.00)

18.75 (27.27)

73.68 (61.54)

32.14 (40.91)

  1. A comparison between the functional annotations of genes known to be regulated by a given protein and the functional annotations of the predicted set of genes. The percentage with related function is calculated against all the genes with functional annotations, while the percentage without functional annotations is calculated against the whole set of predicted genes. The number in parentheses excludes genes known to be part of the corresponding regulon. In cases with high correlation of functional annotations we can propose a related function for genes without functional annotations, as in the Consensus/Patser predictions of ArgR, CRP and PurR (all with correspondences above 90%). Detailed tables are provided as Additional data files.