Table 1 Distribution of KilA-N, Bro-N and associated conserved domains in viral and cellular proteomes
Organism | Host, if phage or virus | Domain architectures |
|---|---|---|
NCLDVs, baculoviruses | Eukaryotes | KilA-N solo (AMV, FPV) |
| Â | Â | KilA-N + Bro-C (AMV, CIV, FPV) |
| Â | Â | KilA-N + T5ORF172 (CIV) |
| Â | Â | KilA-N + RING finger (chordopoxviruses); ectromelia p28 [12] |
| Â | Â | KilA-N + CCCH + RING finger (FPV) |
| Â | Â | Bro-N solo (MSV, AMV, HzNV, LdNV, XnGV) |
| Â | Â | Bro-N + Bro-N (CnBV, CpGV, PxGV) |
| Â | Â | Bro-N + T5ORF172 (CIV, MSV, ESV, baculoviruses) |
| Â | Â | Bro-N + Bro-C (AMV, baculoviruses); BroA, BroD of BmNV [10] |
| Â | Â | Bro-N + Bro-N + Bro-C (HaNV) |
| Â | Â | Bro-N + VSR nuclease (MSV, CIV) |
| Â | Â | Bro-N + Bro-N (CnBV, CpGV) |
| Â | Â | Bro-N + Bro-C (AMV, baculoviruses) |
| Â | Â | MSV199 solo (MSV) |
| Â | Â | MSV199 + T5ORF172 (AMV, MSV, CIV) |
| Â | Â | MSV199 + UVRC (CIV) |
| Â | Â | MSV199 + Bro-C (CIV) |
| Â | Â | Bro-C solo (CIV, DpAV4, AcNV, BmNV, EpNV, LdNV, LsNV, MbNV, OpNV) |
| Â | Â | T5ORF172 solo (CIV, LdNV) |
Proteobacteria | - | KilA-N solo (N. meningitidis, X. fastidiosa) |
| Â | Â | Bro-N solo (N. meningitidis, X. fastidiosa, Pseudomonas aeruginosa) |
| Â | Â | Bro-N (2/3 copies) + XF1559 (X. fastidiosa) |
| Â | Â | XF0704 + Bro-N (X. fastidiosa) |
| Â | Â | Bro-N + P22AR-C (Escherichia coli) |
| Â | Â | KilA-C solo (E. coli) |
|  |  | φ31-ORF238N + P22AR-C (Haemophilus influenzae) |
|  |  | φ31-ORF238N + wHTH (N. meningitidis) |
| Â | Â | XF0704 solo (X. fastidiosa) |
| Â | Â | XF1559 solo (X. fastidiosa) |
| Â | Â | RHA solo (Pasteurella multocida) |
| Â | Â | RHA + D3ORF11-C (H. influenzae) |
| Â | Â | RHA + ASH (Shigella flexneri) |
| Â | Â | D3ORF11-C + P22AR-N (E. coli) |
| Â | Â | bIL285ORF6-N solo (E. coli) |
| Â | Â | ASH solo (E. coli, S. flexneri) |
| Â | Â | T5ORF172 solo (N. meningitidis) |
Low-GC Gram-positive bacteria/ Firmicutes | - | Bro-N solo (Streptococcus pyogenes) |
| Â | Â | Bro-N + HTH (S. pyogenes) |
| Â | Â | Bro-N + KilA-C (S. pyogenes, Staphylococcus aureus) |
| Â | Â | RHA solo (Streptococcuspneumoniae) |
|  |  | φ31-ORF238N + KilA-C (S. pyogenes, S. aureus) |
|  |  | φ31-ORF238N + φSLT-orf81a (Clostridium acetobutylicum) |
| Â | Â | T5ORF172 solo (Bacillus subtilis) |
| Â | Â | KilA-C solo (Lactococcus lactis) |
High-GC Gram-positive bacteria | - | Bro-N solo (Streptomyces coelicolor) |
Phages BP7888, BP933W, BPHK97, BPN15, BPHK620, BPHK022, BPφ-R73 BPP22, BPH-19B, BPP1, BPP4, BPP27, BPφ80, BPT5, BPVT2-Sa | Escherichia coli | Bro-N solo (BPN15) |
| Â | Â | KilA-N + KilA-C; phage P1 - KilA [14] |
| Â | Â | KilA-N + D3ORF11-C (BPHK620) |
| Â | Â | KilA-N + p63C (BP933W, BPHK97) |
|  |  | RHA solo (BPφ80); BPP22 ORF 201 [47] |
| Â | Â | RHA + KilA-C (BPHK022, BP933W, BPP1, BPH-19B, BPHK97, BPHK620, |
| Â | Â | BPVT2-Sa); Reduced on IHF- (ROI) [48] |
| Â | Â | KilA-C solo; bacteriophage P1 antirepressor Ant1/Ant2 [49] |
|  |  | φ31-ORF238N + P22AR-C (BP933W, BPVT2-Sa) |
| Â | Â | D3ORF11-C + P22AR-N (BP933W, BP7888) |
|  |  | ASH solo (BPP4, BPφ-R73, BPN15) |
| Â | Â | bIL285ORF6-N + P22AR-C (BPVT2-Sa) |
| Â | Â | T5ORF172 solo (BPT5, BPP27) |
Phage P22 | Salmonella typhimurium | P22AR-N + Bro-N + P22AR-C; BPP22 antirepressor [33,34] |
| Â | Â | RHA + D3ORF11-C [46] |
Phage APSE-1 | Buchnera aphidicola | RHA (solo) |
| Â | Â | Bro-N (solo) |
Phage D3 | Pseudomonas aeruginosa | KilA-N + D3ORF11-C |
BPφPV83, BPφETA, BPφSLT | Staphylococcus aureus | Bro-N + KilA-C (BPφPV83) |
|  |  | φ31-ORF238N + KilA-C (BPφETA) |
|  |  | φSLT-ORF81a solo (BPφSLT) |
|  |  | RHA solo (BPφSLT) |
BPbIL285, BPbIL286, BPbIL311, BPbIL309, BPpi3, BPφ31.1, BPTP901-1, BPR1T, BPBK5-T, BPLL-H, BPTuc2009 | Lactococcus lactis | Bro-N + KilA-C (BPR1T, BPBK5-T, BPLL-H, BPbIL309) |
| Â | Â | KilA-C solo (BPR1T) |
| Â | Â | RHA solo (BpbIL310, BPbIL311) |
|  |  | φ31-ORF238N + bIL285ORF6-C (BPpi3, BPTuc2009, BPbIL286, BPφ31.1) |
| Â | Â | bIL285ORF6-N + bIL285ORF6-C (BPbIL285, BPTP901-1) |
LcBPA2 | Lactobacillus casei | Bro-N solo |
BPTP-J34, BPSfi21 | Streptococcus thermophilus | φ31-ORF238N + KilA-C |
BPA118 | Listeria monocytogenes | φ31-ORF238N + KilA-C |
BPSpβc2 | Bacillus subtilis | RHA + KilA-C |
BPMx8 (Myxococcal phage) | Myxococcus xanthus | Bro-N + p63C |