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Table 1 Lists of specificity-determining residues as predicted by different methods

From: Using orthologous and paralogous proteins to identify specificity determining residues

Method DNA-binding Domain Ligand-binding Domain
Model 1, eq (3) P < 10-5I > 1.0 : 15,16,50,55 P < 10-5I > 1.5 : 98,114,122,146,147,160,221,249
Model 1, eq (4) P < 10-4I > 1.0 : 15,16,50,55 P < 10-4I > 1.5 : 98,114,146,160,221
Model 2 P < 10-2 : 15,16,55 P < 10-2 : 85,98,122,146,160,221,246,249
  1. Numbering is according to 1wet PDB file. See Supplementary Information for equations and details.