TY - JOUR AU - Hugenholtz, Philip PY - 2002 DA - 2002/01/29 TI - Exploring prokaryotic diversity in the genomic era JO - Genome Biology SP - reviews0003.1 VL - 3 IS - 2 AB - Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes - out of 35 bacterial and 18 archaeal phylum-level lineages. This bias is beginning to be rectified by the use of phylogenetically directed isolation strategies and by directly accessing microbial genomes from environmental samples. SN - 1474-760X UR - https://doi.org/10.1186/gb-2002-3-2-reviews0003 DO - 10.1186/gb-2002-3-2-reviews0003 ID - Hugenholtz2002 ER -