Figure 2

Possible outcomes of screening glycan libraries. (a) Some lectins, such as the selectin cell-adhesion molecules, will recognize a few specific endogenous mammalian glycans with related structures, such as the sialyl-Lewis glycans shown. (b) Other lectins, such as the macrophage mannose receptor, will bind broader classes of endogenous and microbial glycans, such as those shown below the array; the receptor is shown recognizing structures that bear terminal mannose or N-acetylglucosamine residues.