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Table 3 Phenotypes for which QTLs have been generated using strains that have whole genome draft sequence available

From: In silicodiscovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases

 

Phenotype

Number of QTLs (B6xD2)

1

Alcohol drinking - preference

7

2

Alcohol drinking - acceptance

1

3

Alcohol conditioned taste aversion

3

4

Cocaine seizures

3

5

Morphine preference

1

6

Morphine analgesia

2

7

Screen test sensitivity

8

8

Ethanol-induced locomotor activity

3

9

Basal activity

1

11

Acute alcohol withdrawal

5

12

Acute pentobarbital withdrawal

3

13

Chronic alcohol withdrawal

3

14

LORR duration

4*

15

LORR Bec

14*

16

Free-choice ethanol consumption

6*

17

Behavioral effect of stress

7*

18

Porphyria

3

19

Liver injury and porphyria

3

20

Lymphocyte proportion B220 (%)

2

21

Lymphocyte proportion CD4 (%)

1†

22

Lymphocyte proportion CD8 (%)

1

23

Hepatic lipid peroxidation potential

1

24

Peak bone mass

16*

25

Variation in TRBV4 expansion

2

26

Maximal electroshock seizure threshold

4

27

Variation in cerebellar size

4

28

Variation in IGL volume

1

29

Susceptibility to mycobacterium tuberculosis

2, 1†

30

Acute behavioral sensitivity to paraoxon

6*

31

Circadian period of locomotor activity

1†

32

Short-term intake of saccharin

1

33

Short-term intake of sucrose

1

34

Short-term intake of quinine

1

35

Testicular weight

1

36

Bone density

6

37

Contextual fear conditioning

5

38

Hypothermic sensitivity to quinpirole

1

39

Tolerance to quinpirole

1†

40

Sensitivity and tolerance to quinpirole-induced hypothermia

1†

41

Baseline locomoter activity

3†

42

Locomotor sensitivity to quinpirole

1†

43

Hypnotic sensitivity to ethanol

1*, 1†

44

Body weight

1

45

Tail length

1

46

Methamphetamine responses

 
 

   Chewing

5

 

   Climbing

14

 

   Home cage locomotor activity

20

 

   Body temperature change

22

47

Pcp-induced behavior

3*

48

Amp-induced behavior

6*

49

Antinociceptive responsiveness to N2O

7

50

Corticosterone response to ethanol

5

51

High-affinity choline uptake

1†

 

Phenotype

Number of QTLs (B6xA/J)

52

Cocaine-induced locomotor activity

2

53

Seizure susceptibility (beta-CCM administration)

3

54

Habituated open field behavior

2, 5†

55

Hormone-induced ovulation rate

2, 5†

56

Light-to-dark transition behavior

3, 5†

57

Center time behavior

5†

58

Initial ambulation in the open field

1, 4†

59

Vertical rearings

1, 2†

60

Trypanosomosis resistance

1

61

Nickel-induced acute lung injury

1, 2†

62

PKC-alpha content

1

63

PKC activity

1

 

Total number of QTLs

276

  1. *QTLs identified as suggestive in the original publications. †QTLs identified as provisional in the original publications.