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Figure 5 | Genome Biology

Figure 5

From: The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations

Figure 5

Schematic representation of the possible mechanisms of evolution of multidomain protein kinases with more than one homologous but distinct non-kinase domain, as exemplified in the case of the Syk family of cytoplasmic tyrosine kinases. (a) Duplication of the SH2 domain followed by distinct functional specialization of duplicated domains; (b) Recruitment of two homologous but distinct SH2 domains by domain fusion.

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