Figure 1

Schematic representation of uncommon domain combinations in protein kinases encoded in the human genome. (a) MARK-4 (ENSP246363); (b) IKK (ENSP220806); (c) DMPK (myotonic dystrophy kinase)-like protein kinase (ENSP216542); (d) function unknown (ENSP232797); (e) stathmin-associated kinase(ENSP235784); (f) non-receptor tyrosine kinase associated with Cdc42 (ENSP081325); (g) protein kinase-R (ENSP233057); (h) function unknown (ENSP251707); (i) MAP kinase kinase (gi3652062); (j) protein kinase, function unknown (ENSP234972); (k) Trio kinase (ENSP252004). Protein kinase domains are shown in red and the other domains are labeled as follows: CNH, Citron Nik1-like kinase homology domain; DAGPE, diacylglycerol/phorbol ester-binding domain; DSRM, double-stranded RNA-binding motif; GEF, guanine-nucleotide exchange factor; HEAT, a conserved domain in huntingtin, elongation factor 3, a-regulatory subunit of PP2A and Tor1 protein; Ig, immunoglobulin domain; KA1, kinase-associated domain; OPR, octicosapeptide repeat; PH, pleckstrin homology domain; RRM, RNA recognition motif; SH3, Src homology 3 domain; TM, transmembrane region; UBA, ubiquitin-associated domain; Ubiqb, ubiquitin domain. In (k) the amino- and carboxy-terminal RhoGEF domains are known to bind to Rho and Rac GTPases, respectively.