Figure 4

Classified polytopic membrane domains in 26 genomes. (a) The dark-green bars represent the percentage of polytopic membrane domains that are classified in each genome, using only classified families with at least four members. When classified families containing two or three members are included in this analysis, the additional coverage is represented by light-green bars. (b) The proportion of polytopic membrane domains classified by different methods in all genomes studied. Most polytopic membrane domains are identified by direct ID match and sequence-similarity (FASTA) match to members of classified Pfam-A families (green and light-green bars) and Pfam-B families (yellow and light-yellow bars). A small proportion of polytopic membrane domains are clustered on the basis of their sequence similarity (gray bars). For abbreviations for genomes, see Materials and methods.