Figure 1From: Genomic analysis of membrane protein families: abundance and conserved motifsClassification of polytopic membrane domains. (a) Procedure for classifying polytopic membrane domains. Through automatic classification and manual examination, 228 Pfam-A, 299 Pfam-B and 121 clustered families were classified. (b) An example profile (PF01618) of a classified family of polytopic membrane domains consists of (from top to bottom): sequence alignment; an averaged hydrophobicity plot based on GES hydrophobicity value; consensus sequence displayed by sequence logo with conserved residues in hydrophobic regions highlighted; consensus sequences of TM-helices, where only conserved amino acids are shown in the single-letter code (with the remainder represented by "x").Back to article page