Figure 1

Aquaporin structure. A schematic of the three-dimensional structure of AQP based on structural studies of human AQP1 and E. coli GLP-F [15,22-25,27]. Transmembrane domains were determined according to [87]. The highly conserved NPA motif located in the middle of the pore is shown in blue with white lettering, as is the corresponding NPG motif. The charged residues Asp (D), Glu (E), Lys (K) and Arg (R) are shown in red, and Ser (S) and Thr (T) residues in blue. The latter are potential phosphorylation sites. The four Cys (C) residues are in green and His (H) in yellow.