Figure 3

Substrate specificity within the Iα family of cyclohexadienyl mutase. The substrates and products of chorismate mutase (middle), isochorismate mutase (top) and 4-amino-4-deoxy-chorismate mutase (bottom) are shown at the right. Enzymes from species shown on the left that are known (but see text for PchB) to catalyze the reactions shown on the right are color coded to correspond. Chorismate mutase proteins or domains from selected organisms (see Figure 4 legend for organism abbreviations) are shown as a phylogram tree. The tree shown was obtained with the Phylip program using the input of a Multalign multiple alignment [51]. Bootstrap values over 50% (500 iterations) determine the placement of solid lines, which show significant clustering relationships.