Amino acid alignments of the novel NR sequences FXR-r and HNF4γ-r. (a) FXR-r amino acid alignment with FXR (NR1H4). The nucleotide sequences from complete and ordered clone AL358372 contained eight fragments with amino acid sequence similarity with FXR (from 5'-3' relative to FXR-r, nucleotide positions 13144-13480; 15053-15199; 21541-21672; 21781-21879; 22015-22115; 23681-23795; 24486-23795; 27041-27262). The positions of the intron gaps within FXR-r and FXR are boxed. Positions of termination codons within FXR-r are indicated by an asterisk. (b) HNF4γ-r amino acid alignment with HNF4γ (NR2A2). The complete and ordered clones AL449103 and AL138997 contained contiguous HNF4γ-r sequence. Seven frameshifts (indicated by asterisks) were required to preserve the reading frame of HNF4γ-r relative to HNF4γ. Intron locations in the HNF4γ gene are boxed.