From: Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
Human BIRPs and | Size (kDa) | Map position | Expression of mRNA | Diseases associated with | References |
---|---|---|---|---|---|
alternative names | Â | of gene | Â | chromosomal rearrangements, | Â |
 |  |  |  | gene amplification or deletion |  |
XIAP/MIHA/ | 57 | Xq25 | Detected in all adult tissues examined | Â | |
hILP/BIRC4 | Â | Â | Â | Â | Â |
cIAP-1/MIHB/ | 70 | 11q22-q23 | Detected in all adult tissues examined, | Â | |
HIAP2/BIRC2 | Â | Â | with highest levels in thymus, testis | Â | Â |
 |  |  | and ovary |  |  |
cIAP-2/MIHC/ | 68 | 11q22-q23 | Detected in all adult tissues examined, | In marginal zone cell lymphomas of | |
HIAP1/BIRC3 | Â | Â | with highest levels in spleen and | the mucosa-associated lymphoid tissue, | Â |
 |  |  | thymus | API2, the gene encoding cIAP-2, is often |  |
 |  |  |  | rearranged together with the novel gene |  |
 |  |  |  | MLT at 18q21 resulting in an API2-MLT |  |
 |  |  |  | fusion |  |
LIVIN/ML-IAP/ | 31 | 20q13.3 | Detected in embryonic tissue | The region is frequently amplified in | |
KIAP/BIRC7 | Â | Â | and some adult tissues. | melanomas, colon, lung and colorectal | Â |
 |  |  | Elevated levels in cancer cell | malignancies |  |
 |  |  | lines, particularly melanoma cell lines |  |  |
NAIP/BIRC1 | 156 | 5q13.1 | Detected only in liver and placenta | Deletions of the NAIP genes often occur | |
(6 genes) | Â | Â | by northern blot analysis but was | in individuals with spinal muscular atrophy | Â |
 |  |  | detected in spinal cord mRNA by | but deletions in the nearby gene SMN are |  |
 |  |  | RT-PCR | the most likely cause of disease |  |
Survivin/BIRC5 | 17 | 17q25 | Cell-cycle-dependent expression, | Â | |
 |  |  | restricted to tissues in which there are |  |  |
 |  |  | dividing cells; for example, embryonic |  |  |
 |  |  | tissue, solid tumors and transformed |  |  |
 |  |  | cell lines. Expression is absent from |  |  |
 |  |  | most normal adult tissue |  |  |
BRUCE/BIRC6 | 528 | 2p21-p22 | Expression of mRNA is detectable in | Â | [22] |
 |  |  | most adult tissues, with high levels in |  |  |
 |  |  | brain and kidney |  |  |