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Table 2 Linker histone variants with potential unique functions

From: Histone variants: are they functionally heterogeneous?

Variant Organism Essential for Proposed function
   viability?  
H1A Xenopus Not known Specific gene repression during
    development
H1t Mouse No Promotion of open chromatin
    structure; recombination during
    spermatogenesis
H10 Mouse No Repression of gene expression;
    stabilization of chromatin
    structure during differentiation
H1c Mouse No Activation of gene expression
H1S-2, Human No Activation of gene expression;
H1S-4    selective depletion from active
    genes