Skip to main content

Table 1 Core histone variants with potential unique functions

From: Histone variants: are they functionally heterogeneous?

Variant Percentage of Essential for Proposed function
  amino-acid viability?  
  identity to   
  major isotype (%)   
CENP-A 62 Yes (mouse) Kinetochore
MacroH2A 64 (in histone Not known X-chromosome
  region)   inactivation; gene
H2A-Bbd 42 Not known Transcriptional
H2A.Z 59 Yes Unclear; altered higher-
   (mouse, flies, order chromatin
   Tetrahymena) structure