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Table 1 Core histone variants with potential unique functions

From: Histone variants: are they functionally heterogeneous?

Variant Percentage of Essential for Proposed function
  amino-acid viability?  
  identity to   
  major isotype (%)   
CENP-A 62 Yes (mouse) Kinetochore
    assembly
MacroH2A 64 (in histone Not known X-chromosome
  region)   inactivation; gene
    expression
H2A-Bbd 42 Not known Transcriptional
    activation
H2A.Z 59 Yes Unclear; altered higher-
   (mouse, flies, order chromatin
   Tetrahymena) structure