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Table 1 Summary of previously characterized genes disrupted by gene trap mutagenesis

From: Gene trapping identifies transiently induced survival genes during programmed cell death

Gene for

Type of protein

Function

Accession number

Net1A

GEF for Rho-family GTPases

DH-domain containing oncogene

AJ010045

PEM2

GEF for Rho-family GTPases

DH-domain containing oncogene

AJ250425

(KIAA0424)

   

PIP5K type Iβ

Serine-threonine phosphokinase

Cell survival

NM_008847

PIP5K type Iγ /Tjp3

Serine-threonine phosphokinase

Cell survival

AB006916

p38-G4

DNA-binding protein

Cell cycle regulated protein associated with proliferation

X84789

YB-1

Transcription factor

Represses Fas transcription, activates MDR1 transcription

M60419

IL-12 receptor

Cytokine receptor

Inhibits Fas/FasL signal transduction

NM_008353

VMAT-2

Vesicular monoamine transporter

Sequesters neuro-toxins in synaptic vesicles

L23205

AlkB

Enzyme

Protects DNA against alkylation

NM_006020

Rec8

Enzyme

DNA double-strand break repair

AF006264

Mre11/Rad50

Enzyme

DNA double-strand break repair

NM_009012

ICAM-4

Cell-surface molecule

Mediates intercellular adhesion

AF296282

   

NM_001544

Nitrilase

Enzyme

Nitrogen metabolism, tumor suppression

NM_012049

Myosin I-β

Structural

Cell mobility

AY007255

   

X99638

Hexokinase

Enzyme

Glycolysis

JO5277