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Table 1 Localization and function of selected Rab GTPases

From: The Rab GTPase family

Name Yeast homolog Localization Expression Function
Rab1a Ypt1p ER/cis-Golgi U ER-Golgi transport
Rab2a   ER/cis-Golgi U Golgi-ER retrograde transport
Rab3a   SV Neurons Regulation of neurotransmitter release
Rab4a   EE U Endocytic recycling
Rab5a Ypt51p EE, CCV, PM U Budding, motility and fusion in endocytosis
Rab6a Ypt6p Golgi U Retrograde Golgi traffic
Rab7 Ypt7p LE U Late endocytic traffic
Rab8a Sec4p TGN, PM U TGN-PM traffic
Rab9a   LE U LE-TGN traffic
Rab11a Ypt31p RE, TGN U Endocytic recycling via RE and TGN
Rab27a   Melanosomes Melanocytes Movement of lytic granules and
   Granules Platelets melanosomes towards PM
  1. See [3,4,39] for references and further details. Compartment abbreviations: CCV, clathrin-coated vesicles; EE, early endosomes; ER, endoplasmic reticulum; LE, late endosome; PM, plasma membrane; RE, recycling endosome; SV, synaptic vesicle; TGN, trans-Golgi network; U, ubiquitous.