Figure 4

Mapping of conserved paralogous gene clusters containing selected members of the EGF, SLC4A, ANK and FGF families. Numbers refer to GB4 RH map positions of genes or their closest mapped markers, if such positions are known or can be inferred from HTGS and STS data. On 5q31-3, RH-inferred gene order was superseded by sequence data, and is not shown. On 8p21-12, the break in the line indicates a possible intracluster rearrangement. For clusters that do not contain genes representing each of the four families, additional genes belonging to the unrepresented families are predicted. EGF family members shown: TGFA, TDGF1, BTC (betacellulin), EGF, HEGFL, NRG1, NRG3; EGF genes not shown: AREG and EREG (4q13-21), NRG2 (5q31). SLC4A genes not shown: SLC4A8 (12q13), SLC4A10 (2q31), HNBC7 (1p32-31). KIAA0697 (a long-insert cDNA from RIKEN large-scale gene discovery projects) is highly homologous to the unique middle domain of ANKfc and is therefore included as a candidate novel ankyrin-family gene despite the absence of ankyrin repeats from its cDNA. FGF gene not shown: FGF20 (8p13-22).