A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes

Table 1 Pairwise correlations between measures of response to genome GC content

All pairs of measures are highly correlated. Critical values: for amino acids (n = 21 including stop codons), r of 0.9 corresponds to P = 3 × 10 ^-8. For codons (n = 64), r of 0.9 corresponds to P = 5 × 10^-24. The x intercept is transformed as x' = 1/(50% - x) to minimize the effects of extreme values with large errors: this occurs for codons and amino acids with very flat slopes.

ISSN: 1474-760X