Table 2 Ontological classification of 22,339 human gene products. Each transcriptional unit and HINT transcript (in parentheses) was assigned to a unique biological function or process.
Biological function | Number of transcripts | Biological process | Number of transcripts |
|---|---|---|---|
Transcription factor | 958 (306) | Carbohydrate metabolism | 281 (84) |
Translation factor | 62 (27) | Nucleotide and nucleic acid metabolism | 173 (51) |
RNA binding | 142 (41) | DNA replication | 240 (126) |
Ribosomal protein | 232 (130) | Transcription | 1,059 (651) |
Cell cycle regulator | 42 (16) | RNA processing | 204 (59) |
Structural protein | 145 (48) | Amino Acid and derivative metabolism | 87 (29) |
Cytoskeleton structural protein | 329 (181) | Protein biosynthesis | 264 (162) |
Extracellular matrix | 361 (87) | Protein modification | 235 (88) |
Actin binding | 66 (25) | Protein targeting | 26 (5) |
Motor protein | 245 (77) | Protein degradation | 136 (45) |
Chaperone | 87 (27) | Proteolysis and peptidolysis | 96 (36) |
Enzyme | 2,664 (1,404) | Lipid metabolism | 424 (187) |
Protein kinase | 895 (484) | Monocarbon compound metabolism | 9 (3) |
Protein kinase inhibitor | 19 (12) | Coenzyme and prosthetic group metabolism | 92 (29) |
Protein phsophatase | 43 (7) | Steroid compound metabolism | 40 (10) |
Protein phsophatase inhibitor | 17 (3) | Prostaglandin metabolism | 12 (3) |
Protease | 441 (255) | Transport | 549 (288) |
Protease inhibitor | 92 (37) | Electron transport | 491 (273) |
Enzyme activator | 18 (3) | Ion transport | 302 (90) |
Enzyme inhibitor | 14 (4) | Small molecular transport | 19 (9) |
Alkyl transfer | 17 (3) | Neurotransmitter transport | 9 (3) |
Amide transfer | 15 (3) | Ion homeostasis | 201 (57) |
Carbonyl transfer | 191 (38) | Organelle organization and biogenesis | 408 (254) |
Hydroxyl transfer | 13 (6) | Nuclear organization and biogenesis | 1,380 (647) |
Phosphoryl transfer | 823 (281) | Cytoplasm organization and biogenesis | 42 (20) |
Oxireduction | 148 (76) | Meiosis | 15 (2) |
Transmembrane protein | 184 (48) | Mitosis | 25 (6) |
Receptor | 921 (478) | Cell cycle | 271 (100) |
G protein-linked receptor | 164 (106) | DNA packaging | 15 (6) |
Defense/immunity protein | 353 (164) | DNA repair | 132 (41) |
Ligand binding or carrier | 691 (331) | DNA recombination | 31 (3) |
Ion channel | 245 (141) | Methylation | 185 (53) |
Oncogene | 128 (42) | Signal transduction | 1,231 (383) |
Tumor suppressor | 8 (6) | Growth regulation | 15 (4) |
Growth factor | 95 (40) | Differentiation | 24 (6) |
Hormone | 42 (14) | Apoptosis | 160 (49) |
Cell communication | 247 (84) | Angiogenesis | 11 (4) |
Cell adhesion | 433 (252) | Defense/immunity | 112 (49) |
| Â | Â | Detoxification | 33 (15) |
| Â | Â | Stress response | 90 (41) |
| Â | Â | Developmental process | 278 (99) |
| Â | Â | Neurogenesis and regeneration | 147 (43) |
| Â | Â | Physiological process | 159 (43) |
| Â | Â | Sensory perception | 292 (65) |
Functionally classified | 12,334 (5,204) | Process classified | 10,005 (4,225) |