Skip to main content

Table 2 Ontological classification of 22,339 human gene products. Each transcriptional unit and HINT transcript (in parentheses) was assigned to a unique biological function or process.

From: A draft annotation and overview of the human genome

Biological function Number of transcripts Biological process Number of transcripts
Transcription factor 958 (306) Carbohydrate metabolism 281 (84)
Translation factor 62 (27) Nucleotide and nucleic acid metabolism 173 (51)
RNA binding 142 (41) DNA replication 240 (126)
Ribosomal protein 232 (130) Transcription 1,059 (651)
Cell cycle regulator 42 (16) RNA processing 204 (59)
Structural protein 145 (48) Amino Acid and derivative metabolism 87 (29)
Cytoskeleton structural protein 329 (181) Protein biosynthesis 264 (162)
Extracellular matrix 361 (87) Protein modification 235 (88)
Actin binding 66 (25) Protein targeting 26 (5)
Motor protein 245 (77) Protein degradation 136 (45)
Chaperone 87 (27) Proteolysis and peptidolysis 96 (36)
Enzyme 2,664 (1,404) Lipid metabolism 424 (187)
Protein kinase 895 (484) Monocarbon compound metabolism 9 (3)
Protein kinase inhibitor 19 (12) Coenzyme and prosthetic group metabolism 92 (29)
Protein phsophatase 43 (7) Steroid compound metabolism 40 (10)
Protein phsophatase inhibitor 17 (3) Prostaglandin metabolism 12 (3)
Protease 441 (255) Transport 549 (288)
Protease inhibitor 92 (37) Electron transport 491 (273)
Enzyme activator 18 (3) Ion transport 302 (90)
Enzyme inhibitor 14 (4) Small molecular transport 19 (9)
Alkyl transfer 17 (3) Neurotransmitter transport 9 (3)
Amide transfer 15 (3) Ion homeostasis 201 (57)
Carbonyl transfer 191 (38) Organelle organization and biogenesis 408 (254)
Hydroxyl transfer 13 (6) Nuclear organization and biogenesis 1,380 (647)
Phosphoryl transfer 823 (281) Cytoplasm organization and biogenesis 42 (20)
Oxireduction 148 (76) Meiosis 15 (2)
Transmembrane protein 184 (48) Mitosis 25 (6)
Receptor 921 (478) Cell cycle 271 (100)
G protein-linked receptor 164 (106) DNA packaging 15 (6)
Defense/immunity protein 353 (164) DNA repair 132 (41)
Ligand binding or carrier 691 (331) DNA recombination 31 (3)
Ion channel 245 (141) Methylation 185 (53)
Oncogene 128 (42) Signal transduction 1,231 (383)
Tumor suppressor 8 (6) Growth regulation 15 (4)
Growth factor 95 (40) Differentiation 24 (6)
Hormone 42 (14) Apoptosis 160 (49)
Cell communication 247 (84) Angiogenesis 11 (4)
Cell adhesion 433 (252) Defense/immunity 112 (49)
   Detoxification 33 (15)
   Stress response 90 (41)
   Developmental process 278 (99)
   Neurogenesis and regeneration 147 (43)
   Physiological process 159 (43)
   Sensory perception 292 (65)
Functionally classified 12,334 (5,204) Process classified 10,005 (4,225)