Granzymes: a family of lymphocyte granule serine proteases

Table 1 Properties of granzymes in humans and rodents

Granzyme	Species	Activity	Predicted cleavage	M_r (× 10³)	Cellular expression
A	Mouse, human, rat	Tryptase	Lysine, arginine	65^*	CTLs, NK cells, γδ T cells and thymocytes
B	Mouse, human, rat	Asp-ase	Aspartic acid > glutamic acid	32	CTLs, NK cells, γδ T cells and thymocytes
C	Mouse, rat	Unknown	Asparagine or serine	27	CTLs
D	Mouse	Unknown	Hydrophobic	35-50	CTLs
E	Mouse	Unknown	Hydrophobic	35-45	CTLs
F	Mouse, rat	Unknown	Hydrophobic	35-50	CTLs
G	Mouse	Unknown	Hydrophobic	30	CTLs
H	Human	Chymase	Phenylalanine > tyrosine	32	CTLs and NK cells
J	Rat	Unknown	Unknown	30	Unknown
M	Mouse, human, rat	Met-ase	Methionine > leucine	30	NK cells

^*Granzyme A is the only granzyme that is found as a homodimer and its relative molecular mass (M_r) is therefore higher.

ISSN: 1474-760X