Gene name (GI numbers)* | Domain organization†| Phyletic distribution‡ | Predicted function§ |
---|---|---|---|
Chlamydia trachomatis-Chlamydia muridarum-Chlamydophila pneumoniae | |||
CT079/CP0424/TC0351 (4376613, 3328474, 7190393) | Signal peptide, four transmembrane regions (TMs) | Aquifex aeolicus | Membrane protein, potential receptor |
CT288/CP0709/TC0561 (4376321, 3328702, 7190602) | Four TMs, coiled coil | Chlamydia-specific, distant additional paralogs | Membrane protein, potential receptor |
CT656/CP0029/TC0027 (4377021, 3329106, 7190067) | NA | Chlamydia-specific | Unknown |
CT006/CP0311/TC0274 (4376725, 3328394, 7190315) | Three TMs | Chlamydia-specific | Membrane protein, potential receptor |
CT036/CP0642/TC0306 (4376393, 3328427, 7190347) | Two TMs | Chlamydia-specific | Membrane protein, potential receptor |
CT147/CP0623/TC0424 (4376417, 3328548, 7190467) | Three-four TMs, coiled coil | Chlamydia-specific | Membrane protein, potential receptor |
CT695/CP0071/TC0067 (4376977, 3329149, 7190102) | Low sequence complexity | Chlamydia-specific | Non-globular protein of unknown function |
Pyrococcus horikoshii-abyssi-furiosus | |||
PH0310 (301754, 3256700, 5459075) | Cathepsin-like cysteine protease, signal peptide, three to seven TMs | Orthologs only in pyrococci; distantly related cathepsins in animals | Pyrolysin - hyperthermostable membrane protease |
PH1993, PAB1163 (1849588, 3258437, 5459195) | Signal peptide, deacetylase superfamily hydrolase domain | Methanococcus jannaschii, Pseudomonas aeruginosa, Mycobacterium tuberculosis (COG3233) | Predicted secreted deacetylase |
PH1708, PAB2041 (76490, 3258139, 5457898) | Signal peptide, low-sequence-complexity regions | Pyrococcus-specific | Secreted, non-globular protein |
PH0103, PAB0064 (693117, 3256489, 5457538) | Type IV restriction endonuclease, Eco57I homolog | Sporadic distribution in archaea and bacteria (COG2810) | Predicted restriction endonuclease |
PH1340, PAB1824 (1411868, 3257763, 5458235) | NA | Pyrococcus-specific | Unknown |
PH0996, PAB0660 (984613, 3257410, 5458405) | Signal peptide, coiled coil, low complexity | Pyrococcus-specific | Secreted, non-globular protein |
PH0617, PAB1428 (506618, 3257023, 5458851) | Signal peptide, seven TMs | Pyrococcus-specific | Integral membrane protein |
PH0692, PAB0621 (917540, 3257100, 5458351) | Signal peptide, low sequence complexity regions | Pyrococcus-specific | Secreted, non-globular protein |
PH0228, PAB0142 (1132938, 3256617, 5457641) | Acetate/butyrate kinase domain | Conserved orthologs in some archaea (Archaeoglobus, Aeropyrum); poorly conserved orthologs in most bacteria (COG2441) | Predicted butyrate kinase |
PH1703, PAB0312(1599997, 3258134, 5457902) | Signal peptide, low sequence complexity regions | Pyrococcus-specific | Secreted small protein |
PH0538, PAB0257 (396645, 3256944, 5457867) | Signal peptide, four TMs | Pyrococcus-specific (distant homologs in some archaea and bacteria) | Integral membrane protein |
Homo sapiens-Mus musculus-Rattus norvegicus | |||
Interferon precursor (32680, 309328, 2317784) | Signal peptide, interferon gamma domain | Vertebrate-specific | Interferon gamma |
Interferon-beta-2 (32674, 52702, 204926) | Signal peptide, interleukin 6 domain | Vertebrate-specific | Interleukin 6 (interferon-beta-2) |
Glycoprotein 34 (219666, 551081, 3779224) | Tumor necrosis factor domain, one TM | Mammal-specific | OX40 ligand (membrane-associated cytokine) |
Uteroglobin (23132, 49691, 206040) | Signal peptide, uteroglobin domain | Mammal-specific | Secreted phospholipid-binding protein |
Eotaxin (1280141, 995911, 1707665) | Signal peptide, interleukin 8 domain | Vertebrate-specific | Eotaxin (small inducible CxC cytokine) |
Taste receptor T2R1 (9625043, 10048430, 7262627) | Signal peptide, seven TMs | Mammal-specific | Taste receptor |
Relaxin, H2 (35927, 414781, 57044) | Signal peptide, insulin-like growth factor/relaxin family domain | Mammal-specific | Relaxin |
IgE receptor (34003, 193246, 313673) | Lectin C-type domain (CTL), one transmembrane segment, coiled coil domain | Orthologs only in mammals, lectin domain in all animals | Immunoglobulin E receptor |
Lactadherin (1381162, 4586464, 1620007) | Signal peptide, epidermal growth factor-like domains, coagulation factor 5/8 C-terminal (discoidin) domain (2) | Orthologs in mammals only, discoidin domain animal-specific | Lactadherin (secreted integrin- and phospholipid-binding protein, involved in antimicrobial defense) |
Secretin preproprotein (11345450, 313711, 206888) | Glucagon-like hormone domain | Mammal-specific | Secretin |
C-reactive protein (30213, 50564, 203592) | Signal peptide, pentraxin/C-reactive protein family domain | Vertebrate-specific | C-reactive protein, phosphorylcholine-binding, involved in host defense against bacterial infection |
Preproapolipoprotein AI (28772, 50015, 202945) | Signal peptide, apolipoprotein A1/A4/E family domain | Vertebrate-specific | Preproapolipoprotein AI |
EDAG-1 (7677357, 11244774, 11140172) | Regions of low sequence complexity | Mammal-specific | Unknown |
Deoxyribonuclease II beta (11427442, 6175550, 6470131) | Signal peptide, deoxyribonuclease | Mammals, nematodes, insects (animal-specific) | Deoxyribonuclease (lysosomal enzyme, implicated in apoptosis) |
Hydroxysteroid sulfotransferase (306702, 496152, 2104492) | Sulfotransferase domain | Animals, plants, mycobacteria | Hydroxysteroid sulfotransferase |
Hydroxy acid oxidase 3 (7208440, 8926328, 311833) | FMN-dependent oxidoreductase | All eukaryotes, many bacteria | Hydroxy acid oxidase (peroxisomal enzyme) |